Costimulation Blockade Disrupts CD4

Abatacept / pharmacology B-Lymphocytes / drug effects Biomarkers / blood CD28 Antigens / immunology CD4-Positive T-Lymphocytes / drug effects CD8-Positive T-Lymphocytes / drug effects Cells, Cultured Diabetes Mellitus, Type 1 / blood Humans Immunologic Memory / drug effects Insulin-Secreting Cells / drug effects T-Lymphocytes, Regulatory / drug effects

Journal

Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R

Informations de publication

Date de publication:
15 06 2020
Historique:
received: 04 12 2019
accepted: 13 04 2020
pubmed: 15 5 2020
medline: 13 2 2021
entrez: 15 5 2020
Statut: ppublish

Résumé

We previously reported that costimulation blockade by abatacept limits the decline of β-cell function and the frequency of circulating CD4

Identifiants

DOI: 10.4049/jimmunol.1901439 PMID: 32404353 PMC: PMC7378361
pubmed: 32404353
pii: jimmunol.1901439
doi: 10.4049/jimmunol.1901439
pmc: PMC7378361
mid: NIHMS1598825
doi:

Substances chimiques

Biomarkers 0
CD28 Antigens 0
Abatacept 7D0YB67S97

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3129-3138

Subventions

Organisme : NIDDK NIH HHS
ID : U01 DK085476
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061010
Pays : United States
Organisme : Department of Health
Pays : United Kingdom
Organisme : NIDDK NIH HHS
ID : U01 DK103282
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK106993
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061042
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085509
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085466
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103153
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061058
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK106984
Pays : United States
Organisme : NIDDK NIH HHS
ID : DP3 DK101109
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085499
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK107013
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103266
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK107014
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK106994
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK061034
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085461
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK103180
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK085465
Pays : United States

Informations de copyright

Copyright © 2020 by The American Association of Immunologists, Inc.

Références

Front Immunol. 2019 Oct 31;10:2547
pubmed: 31749806
Annu Rev Immunol. 2008;26:453-79
pubmed: 18062768
J Clin Invest. 2013 Feb;123(2):594-9
pubmed: 23281401
Immunol Rev. 2008 Aug;224:166-82
pubmed: 18759926
Immunity. 2015 Jun 16;42(6):1116-29
pubmed: 26084026
Immunity. 2018 Feb 20;48(2):214-226
pubmed: 29466754
Diabetes Care. 2014 Apr;37(4):1069-75
pubmed: 24296850
Diabetes. 2019 Jun;68(6):1240-1250
pubmed: 30894366
Immunity. 2009 Dec 18;31(6):859-71
pubmed: 20064446
Immunity. 2006 Mar;24(3):233-8
pubmed: 16546089
Curr Opin Immunol. 2011 Dec;23(6):746-53
pubmed: 22051340
Int Rev Immunol. 2018;37(4):206-214
pubmed: 29757670
Lancet. 2011 Jul 30;378(9789):412-9
pubmed: 21719096
J Clin Invest. 2018 Aug 1;128(8):3460-3474
pubmed: 29851415
Cold Spring Harb Perspect Med. 2012 Apr;2(4):a007781
pubmed: 22474615
Genes Immun. 2014 Jan;15(1):25-32
pubmed: 24173147
Nat Rev Immunol. 2012 Nov;12(11):749-61
pubmed: 23080391
Bioinformatics. 2014 Oct;30(19):2811-2
pubmed: 24930139
Nat Rev Immunol. 2009 Jul;9(7):514-9
pubmed: 19543226
J Clin Invest. 2020 Jan 2;130(1):480-490
pubmed: 31815738
Bioinformatics. 2016 Sep 15;32(18):2847-9
pubmed: 27207943
Diabetes. 2014 Oct;63(10):3449-57
pubmed: 24834977
Cytometry A. 2015 Jul;87(7):636-45
pubmed: 25573116
Eur J Immunol. 2013 Nov;43(11):2797-809
pubmed: 24258910
Trends Mol Med. 2018 Jul;24(7):642-653
pubmed: 29880309
J Immunol Methods. 2006 Jun 30;313(1-2):161-8
pubmed: 16762359

Auteurs

Martin Eichmann (M)

Peter Gorer Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom; martin.eichmann@kcl.ac.uk.
ORCID: 0000-0002-8675-2822

Roman Baptista (R)

Peter Gorer Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom.
Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London, London SE1 9RT, United Kingdom.

Richard J Ellis (RJ)

Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London, London SE1 9RT, United Kingdom.

Susanne Heck (S)

Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London, London SE1 9RT, United Kingdom.

Mark Peakman (M)

Peter Gorer Department of Immunobiology, Faculty of Life Sciences and Medicine, King's College London, London SE1 9RT, United Kingdom.
Biomedical Research Centre at Guy's and St Thomas' Hospitals and King's College London, London SE1 9RT, United Kingdom.
Institute of Diabetes, Endocrinology and Obesity, King's Health Partners, London, United Kingdom; and.

Craig A Beam (CA)

Department of Biomedical Sciences, Homer Stryker M.D. School of Medicine, Western Michigan University, Kalamazoo, MI 49008.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Globulines › Sérum-globulines › Immunoglobulines › Anticorps › Abatacept › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Antigène CD28 › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Cellules › Cellules cultivées › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Diabète de type 1 › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Mémoire immunologique › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Costimulation Blockade Disrupts CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Costimulation Blockade Disrupts CD4