Major Capsid Protein Synthesis from the Genomic RNA of Feline Calicivirus.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
16 07 2020
Historique:
received: 24 02 2020
accepted: 09 05 2020
pubmed: 15 5 2020
medline: 20 11 2020
entrez: 15 5 2020
Statut: epublish

Résumé

Caliciviruses have a positive-strand RNA genome with a length of about 7.5 kb that contains 2, 3, or 4 functional open reading frames (ORFs). A subgenomic mRNA (sg-RNA) is transcribed in the infected cell, and both major capsid protein viral protein 1 (VP1) and minor capsid protein VP2 are translated from the sg-RNA. Translation of proteins from the genomic RNA (g-RNA) and from the sg-RNA is mediated by the RNA-linked viral protein VPg (virus protein, genome linked). Most of the calicivirus genera have translation mechanisms leading to VP1 expression from the g-RNA. VP1 is part of the polyprotein for sapoviruses, lagoviruses, and neboviruses, and a termination/reinitiation mechanism was described for noroviruses. Vesiviruses have no known mechanism for the expression of VP1 from the g-RNA, and the

Identifiants

pubmed: 32404528
pii: JVI.00280-20
doi: 10.1128/JVI.00280-20
pmc: PMC7375370
pii:
doi:

Substances chimiques

Capsid Proteins 0
RNA, Viral 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 American Society for Microbiology.

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Auteurs

Christian Urban (C)

Institut für Immunologie, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany.

Christine Luttermann (C)

Institut für Immunologie, Friedrich-Loeffler-Institut, Greifswald-Insel Riems, Germany christine.luttermann@fli.de.

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Classifications MeSH