Diverse molecular functions of m
Adenosine
/ analogs & derivatives
Alternative Splicing
Animals
Gene Expression Regulation, Neoplastic
Humans
Methylation
Neoplasms
/ genetics
Nucleic Acid Conformation
Organ Specificity
/ genetics
RNA Processing, Post-Transcriptional
RNA Stability
RNA, Messenger
/ chemistry
Structure-Activity Relationship
Journal
Experimental & molecular medicine
ISSN: 2092-6413
Titre abrégé: Exp Mol Med
Pays: United States
ID NLM: 9607880
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
27
12
2019
accepted:
20
03
2020
revised:
10
02
2020
pubmed:
15
5
2020
medline:
31
7
2021
entrez:
15
5
2020
Statut:
ppublish
Résumé
N
Identifiants
pubmed: 32404927
doi: 10.1038/s12276-020-0432-y
pii: 10.1038/s12276-020-0432-y
pmc: PMC7272606
doi:
Substances chimiques
RNA, Messenger
0
N-methyladenosine
CLE6G00625
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
738-749Subventions
Organisme : Hanyang University (HYU)
ID : HY-2019
Pays : International
Références
Heard, E. & Martienssen, R. A. Transgenerational epigenetic inheritance: myths and mechanisms. Cell 157, 95–109 (2014).
pubmed: 24679529
pmcid: 24679529
doi: 10.1016/j.cell.2014.02.045
Esteller, M. & Pandolfi, P. P. The epitranscriptome of noncoding RNAs in cancer. Cancer Discov. 7, 359–368 (2017).
pubmed: 28320778
pmcid: 5997407
doi: 10.1158/2159-8290.CD-16-1292
Meyer, K. D. et al. Comprehensive analysis of mRNA methylation reveals enrichment in 3’ UTRs and near stop codons. Cell 149, 1635–1646 (2012).
pubmed: 22608085
pmcid: 3383396
doi: 10.1016/j.cell.2012.05.003
Helm, M. & Motorin, Y. Detecting RNA modifications in the epitranscriptome: predict and validate. Nat. Rev. Genet. 18, 275–291 (2017).
pubmed: 28216634
doi: 10.1038/nrg.2016.169
Nachtergaele, S. & He, C. Chemical modifications in the life of an mRNA transcript. Annu. Rev. Genet. 52, 349–372 (2018).
pubmed: 30230927
pmcid: 6436393
doi: 10.1146/annurev-genet-120417-031522
Meyer, K. D. & Jaffrey, S. R. The dynamic epitranscriptome: N6-methyladenosine and gene expression control. Nat. Rev. Mol. Cell Biol. 15, 313–326 (2014).
pubmed: 24713629
pmcid: 4393108
doi: 10.1038/nrm3785
Wang, X. et al. N6-methyladenosine-dependent regulation of messenger RNA stability. Nature 505, 117–120 (2014).
pubmed: 24284625
doi: 10.1038/nature12730
Kasowitz, S. D. et al. Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 14, e1007412 (2018).
pubmed: 29799838
pmcid: 5991768
doi: 10.1371/journal.pgen.1007412
Liu, N. et al. N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions. Nature 518, 560–564 (2015).
pubmed: 25719671
pmcid: 4355918
doi: 10.1038/nature14234
Roundtree, I. A. et al. YTHDC1 mediates nuclear export of N(6)-methyladenosine methylated mRNAs. Elife 6, 1–28 (2017).
doi: 10.7554/eLife.31311
Li, A. et al. Cytoplasmic m(6)A reader YTHDF3 promotes mRNA translation. Cell Res. 27, 444–447 (2017).
pubmed: 28106076
pmcid: 5339832
doi: 10.1038/cr.2017.10
Dominissini, D. et al. Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq. Nature 485, 201–206 (2012).
pubmed: 22575960
doi: 10.1038/nature11112
Schwartz, S. et al. High-resolution mapping reveals a conserved, widespread, dynamic mRNA methylation program in yeast meiosis. Cell 155, 1409–1421 (2013).
pubmed: 24269006
pmcid: 3956118
doi: 10.1016/j.cell.2013.10.047
Clancy, M. J., Shambaugh, M. E., Timpte, C. S. & Bokar, J. A. Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 gene. Nucleic Acids Res 30, 4509–4518 (2002).
pubmed: 12384598
pmcid: 137137
doi: 10.1093/nar/gkf573
Zhong, S. et al. MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor. Plant Cell 20, 1278–1288 (2008).
pubmed: 18505803
pmcid: 2438467
doi: 10.1105/tpc.108.058883
Lin, Z. et al. Mettl3-/Mettl14-mediated mRNA N(6)-methyladenosine modulates murine spermatogenesis. Cell Res 27, 1216–1230 (2017).
pubmed: 28914256
pmcid: 5630681
doi: 10.1038/cr.2017.117
Wang, Y. et al. Publisher correction: N(6)-methyladenosine RNA modification regulates embryonic neural stem cell self-renewal through histone modifications. Nat. Neurosci. 21, 1139 (2018).
pubmed: 29880878
doi: 10.1038/s41593-018-0169-2
Barbieri, I. et al. Promoter-bound METTL3 maintains myeloid leukaemia by m(6)A-dependent translation control. Nature 552, 126–131 (2017).
pubmed: 29186125
pmcid: 6217924
doi: 10.1038/nature24678
Li, Z. et al. FTO plays an oncogenic role in acute myeloid leukemia as a N(6)-methyladenosine RNA demethylase. Cancer Cell 31, 127–141 (2017).
pubmed: 28017614
doi: 10.1016/j.ccell.2016.11.017
Cheng, M. et al. The m(6)A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-kappaB/MYC signaling network. Oncogene 38, 3667–3680 (2019).
pubmed: 30659266
doi: 10.1038/s41388-019-0683-z
Choe, J. et al. mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesis. Nature 561, 556–560 (2018).
pubmed: 30232453
pmcid: 6234840
doi: 10.1038/s41586-018-0538-8
Lin, S., Choe, J., Du, P., Triboulet, R. & Gregory, R. I. The m(6)A methyltransferase METTL3 promotes translation in human cancer cells. Mol. Cell 62, 335–345 (2016).
pubmed: 27117702
pmcid: 4860043
doi: 10.1016/j.molcel.2016.03.021
Wu, R., Jiang, D., Wang, Y. & Wang, X. N (6)-Methyladenosine (m(6)A) methylation in mRNA with a dynamic and reversible epigenetic modification. Mol. Biotechnol. 58, 450–459 (2016).
pubmed: 27179969
doi: 10.1007/s12033-016-9947-9
Wang, P., Doxtader, K. A. & Nam, Y. Structural basis for cooperative function of Mettl3 and Mettl14 methyltransferases. Mol. Cell 63, 306–317 (2016).
pubmed: 27373337
pmcid: 4958592
doi: 10.1016/j.molcel.2016.05.041
Jia, G., Fu, Y. & He, C. Reversible RNA adenosine methylation in biological regulation. Trends Genet. 29, 108–115 (2013).
pubmed: 23218460
doi: 10.1016/j.tig.2012.11.003
Knuckles, P. et al. RNA fate determination through cotranscriptional adenosine methylation and microprocessor binding. Nat. Struct. Mol. Biol. 24, 561–569 (2017).
pubmed: 28581511
doi: 10.1038/nsmb.3419
Slobodin, B. et al. Transcription impacts the efficiency of mRNA translation via co-transcriptional N6-adenosine Methylation. Cell 169, 326–337 e312 (2017).
pubmed: 28388414
pmcid: 5388891
doi: 10.1016/j.cell.2017.03.031
Knuckles, P. et al. Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m(6)A machinery component Wtap/Fl(2)d. Genes Dev. 32, 415–429 (2018).
pubmed: 29535189
pmcid: 5900714
doi: 10.1101/gad.309146.117
Wen, J. et al. Zc3h13 regulates nuclear RNA m(6)A methylation and mouse embryonic stem cell self-renewal. Mol. Cell 69, 1028–1038 e1026 (2018).
pubmed: 29547716
pmcid: 5858226
doi: 10.1016/j.molcel.2018.02.015
Ping, X. L. et al. Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferase. Cell Res 24, 177–189 (2014).
pubmed: 24407421
pmcid: 3915904
doi: 10.1038/cr.2014.3
Patil, D. P. et al. m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nature 537, 369–373 (2016).
pubmed: 27602518
pmcid: 5509218
doi: 10.1038/nature19342
Yue, Y. et al. VIRMA mediates preferential m(6)A mRNA methylation in 3’UTR and near stop codon and associates with alternative polyadenylation. Cell Discov. 4, 10 (2018).
pubmed: 29507755
pmcid: 5826926
doi: 10.1038/s41421-018-0019-0
Pendleton, K. E. et al. The U6 snRNA m(6)A methyltransferase METTL16 regulates SAM synthetase intron retention. Cell 169, 824–835 e814 (2017).
pubmed: 28525753
pmcid: 5502809
doi: 10.1016/j.cell.2017.05.003
Warda, A. S. et al. Human METTL16 is a N(6)-methyladenosine (m(6)A) methyltransferase that targets pre-mRNAs and various non-coding RNAs. EMBO Rep. 18, 2004–2014 (2017).
pubmed: 29051200
pmcid: 5666602
doi: 10.15252/embr.201744940
Shima, H. et al. S-Adenosylmethionine synthesis is regulated by selective N(6)-adenosine methylation and mRNA degradation involving METTL16 and YTHDC1. Cell Rep. 21, 3354–3363 (2017).
pubmed: 29262316
doi: 10.1016/j.celrep.2017.11.092
Jia, G. et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat. Chem. Biol. 7, 885–887 (2011).
pubmed: 22002720
pmcid: 3218240
doi: 10.1038/nchembio.687
Zheng, G. et al. ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertility. Mol. Cell 49, 18–29 (2013).
pubmed: 23177736
doi: 10.1016/j.molcel.2012.10.015
Dina, C. et al. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet. 39, 724–726 (2007).
pubmed: 17496892
doi: 10.1038/ng2048
Fu, Y. et al. FTO-mediated formation of N6-hydroxymethyladenosine and N6-formyladenosine in mammalian RNA. Nat. Commun. 4, 1798 (2013).
pubmed: 23653210
pmcid: 3658177
doi: 10.1038/ncomms2822
Mauer, J. et al. Reversible methylation of m(6)Am in the 5’ cap controls mRNA stability. Nature 541, 371–375 (2017).
pubmed: 28002401
doi: 10.1038/nature21022
Wei, J. et al. Differential m(6)A, m(6)Am, and m(1)A demethylation mediated by FTO in the cell nucleus and cytoplasm. Mol. Cell 71, 973–985 e975 (2018).
pubmed: 30197295
pmcid: 6151148
doi: 10.1016/j.molcel.2018.08.011
Linder, B. et al. Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nat. Methods 12, 767–772 (2015).
pubmed: 26121403
pmcid: 4487409
doi: 10.1038/nmeth.3453
Lence, T. et al. m(6)A modulates neuronal functions and sex determination in Drosophila. Nature 540, 242–247 (2016).
pubmed: 27919077
doi: 10.1038/nature20568
Haussmann, I. U. et al. m(6)A potentiates Sxl alternative pre-mRNA splicing for robust Drosophila sex determination. Nature 540, 301–304 (2016).
pubmed: 27919081
doi: 10.1038/nature20577
Zhao, X. et al. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Cell Res. 24, 1403–1419 (2014).
pubmed: 25412662
pmcid: 4260349
doi: 10.1038/cr.2014.151
Tang, C. et al. ALKBH5-dependent m6A demethylation controls splicing and stability of long 3’-UTR mRNAs in male germ cells. Proc. Natl Acad. Sci. USA 115, E325–E333 (2018).
pubmed: 29279410
doi: 10.1073/pnas.1717794115
Liu, N. et al. N6-methyladenosine alters RNA structure to regulate binding of a low-complexity protein. Nucleic Acids Res 45, 6051–6063 (2017).
pubmed: 28334903
pmcid: 5449601
doi: 10.1093/nar/gkx141
Xiao, W. et al. Nuclear m(6)A reader YTHDC1 regulates mRNA splicing. Mol. Cell 61, 507–519 (2016).
pubmed: 26876937
doi: 10.1016/j.molcel.2016.01.012
Jacobs, E., Mills, J. D. & Janitz, M. The role of RNA structure in posttranscriptional regulation of gene expression. J. Genet Genomics 39, 535–543 (2012).
pubmed: 23089363
doi: 10.1016/j.jgg.2012.08.002
Roost, C. et al. Structure and thermodynamics of N6-methyladenosine in RNA: a spring-loaded base modification. J. Am. Chem. Soc. 137, 2107–2115 (2015).
pubmed: 25611135
pmcid: 4405242
doi: 10.1021/ja513080v
Wang, X. et al. N(6)-methyladenosine modulates messenger RNA translation efficiency. Cell 161, 1388–1399 (2015).
pubmed: 26046440
pmcid: 4825696
doi: 10.1016/j.cell.2015.05.014
Shi, H. et al. YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA. Cell Res 27, 315–328 (2017).
pubmed: 28106072
pmcid: 5339834
doi: 10.1038/cr.2017.15
Hsu, P. J. et al. Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Res 27, 1115–1127 (2017).
pubmed: 28809393
pmcid: 5587856
doi: 10.1038/cr.2017.99
Wojtas, M. N. et al. Regulation of m(6)A transcripts by the 3’->5’ RNA helicase YTHDC2 is essential for a successful meiotic program in the mammalian germline. Mol. Cell 68, 374–387 e312 (2017).
pubmed: 29033321
doi: 10.1016/j.molcel.2017.09.021
Park, O. H. et al. Endoribonucleolytic cleavage of m(6)A-containing RNAs by RNase P/MRP complex. Mol. Cell 74, 494–507 e498 (2019).
pubmed: 30930054
doi: 10.1016/j.molcel.2019.02.034
Du, H. et al. YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complex. Nat. Commun. 7, 12626 (2016).
pubmed: 27558897
pmcid: 5007331
doi: 10.1038/ncomms12626
Zhou, J. et al. Dynamic m(6)A mRNA methylation directs translational control of heat shock response. Nature 526, 591–594 (2015).
pubmed: 26458103
pmcid: 4851248
doi: 10.1038/nature15377
Meyer, K. D. et al. 5’ UTR m(6)A promotes cap-independent translation. Cell 163, 999–1010 (2015).
pubmed: 26593424
pmcid: 4695625
doi: 10.1016/j.cell.2015.10.012
Ries, R. J. et al. m(6)A enhances the phase separation potential of mRNA. Nature 571, 424–428 (2019).
pubmed: 31292544
pmcid: 6662915
doi: 10.1038/s41586-019-1374-1
Zhang, F. et al. Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets. Hum. Mol. Genet. 27, 3936–3950 (2018).
pubmed: 30107516
pmcid: 6216232
Edupuganti, R. R. et al. N(6)-methyladenosine (m(6)A) recruits and repels proteins to regulate mRNA homeostasis. Nat. Struct. Mol. Biol. 24, 870–878 (2017).
pubmed: 28869609
pmcid: 5725193
doi: 10.1038/nsmb.3462
Huang, H. et al. Recognition of RNA N(6)-methyladenosine by IGF2BP proteins enhances mRNA stability and translation. Nat. Cell Biol. 20, 285–295 (2018).
pubmed: 29476152
pmcid: 5826585
doi: 10.1038/s41556-018-0045-z
Wang, Y. et al. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nat. Cell Biol. 16, 191–198 (2014).
pubmed: 24394384
pmcid: 4640932
doi: 10.1038/ncb2902
Chen, Z., Fillmore, C. M., Hammerman, P. S., Kim, C. F. & Wong, K. K. Non-small-cell lung cancers: a heterogeneous set of diseases. Nat. Rev. Cancer 14, 535–546 (2014).
pubmed: 25056707
pmcid: 5712844
doi: 10.1038/nrc3775
Molina, J. R., Yang, P., Cassivi, S. D., Schild, S. E. & Adjei, A. A. Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin. Proc. 83, 584–594 (2008).
pubmed: 18452692
pmcid: 2718421
doi: 10.1016/S0025-6196(11)60735-0
Wei, W., Huo, B. & Shi, X. miR-600 inhibits lung cancer via downregulating the expression of METTL3. Cancer Manag. Res. 11, 1177–1187 (2019).
pubmed: 30774445
pmcid: 6362936
doi: 10.2147/CMAR.S181058
Du, M. et al. MiR-33a suppresses proliferation of NSCLC cells via targeting METTL3 mRNA. Biochem Biophys. Res Commun. 482, 582–589 (2017).
pubmed: 27856248
doi: 10.1016/j.bbrc.2016.11.077
Du, Y. et al. SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function. Nucleic Acids Res 46, 5195–5208 (2018).
pubmed: 29506078
pmcid: 6007514
doi: 10.1093/nar/gky156
Liu, J. et al. m(6)A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression. Biochem. Biophys. Res. Commun. 502, 456–464 (2018).
pubmed: 29842885
doi: 10.1016/j.bbrc.2018.05.175
Chen, J., Odenike, O. & Rowley, J. D. Leukaemogenesis: more than mutant genes. Nat. Rev. Cancer 10, 23–36 (2010).
pubmed: 20029422
pmcid: 2972637
doi: 10.1038/nrc2765
Vu, L. P. et al. The N(6)-methyladenosine (m(6)A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nat. Med. 23, 1369–1376 (2017).
pubmed: 28920958
pmcid: 5677536
doi: 10.1038/nm.4416
Paris, J. et al. Targeting the RNA m(6)A reader ythdf2 selectively compromises cancer stem cells in acute myeloid leukemia. Cell Stem Cell 25, 137–148 e136 (2019).
pubmed: 31031138
pmcid: 6617387
doi: 10.1016/j.stem.2019.03.021
Weng, H. et al. METTL14 inhibits hematopoietic stem/progenitor differentiation and promotes leukemogenesis via mRNA m(6)A modification. Cell Stem Cell 22, 191–205 e199 (2018).
pubmed: 29290617
doi: 10.1016/j.stem.2017.11.016
Sia, D., Villanueva, A., Friedman, S. L. & Llovet, J. M. Liver cancer cell of origin, molecular class, and effects on patient prognosis. Gastroenterology 152, 745–761 (2017).
pubmed: 28043904
doi: 10.1053/j.gastro.2016.11.048
Chen, M. et al. RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2. Hepatology 67, 2254–2270 (2018).
pubmed: 29171881
doi: 10.1002/hep.29683
Zhong, L. et al. YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma. Cancer Lett. 442, 252–261 (2019).
pubmed: 30423408
doi: 10.1016/j.canlet.2018.11.006
Yang, Z. et al. MicroRNA-145 modulates N(6)-methyladenosine levels by targeting the 3’-untranslated mRNA region of the N(6)-methyladenosine binding YTH domain family 2 protein. J. Biol. Chem. 292, 3614–3623 (2017).
pubmed: 28104805
pmcid: 5339747
doi: 10.1074/jbc.M116.749689
DeSantis, C. E., Ma, J., Goding Sauer, A., Newman, L. A. & Jemal, A. Breast cancer statistics, 2017, racial disparity in mortality by state. CA Cancer J. Clin. 67, 439–448 (2017).
pubmed: 28972651
doi: 10.3322/caac.21412
Cai, X. et al. HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g. Cancer Lett. 415, 11–19 (2018).
pubmed: 29174803
doi: 10.1016/j.canlet.2017.11.018
Zhang, C. et al. Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cells. Oncotarget 7, 16 (2016).
Zhang, C. et al. Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m(6)A-demethylation of NANOG mRNA. Proc. Natl Acad. Sci. USA 113, E2047–E2056 (2016).
pubmed: 27001847
doi: 10.1073/pnas.1602883113
Wu, L., Wu, D., Ning, J., Liu, W. & Zhang, D. Changes of N6-methyladenosine modulators promote breast cancer progression. BMC Cancer 19, 326 (2019).
pubmed: 30953473
pmcid: 6451293
doi: 10.1186/s12885-019-5538-z
He, H., Wu, W., Sun, Z. & Chai, L. MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m(6)A-caused stabilization of SEC62. Biochem. Biophys. Res Commun. 517, 581–587 (2019).
pubmed: 31395342
doi: 10.1016/j.bbrc.2019.07.058
Wang, Q. et al. METTL3-mediated m(6)A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significance. Gut (2019). [Epub ahead of print]
Li, Y. et al. Expression of demethylase genes, FTO and ALKBH1, is associated with prognosis of gastric cancer. Dig. Dis. Sci. 64, 1503–1513 (2019).
pubmed: 30637548
pmcid: 6522448
doi: 10.1007/s10620-018-5452-2
Zhang, C. et al. Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancer. Cancer Med. 8, 4766–4781 (2019).
pubmed: 31243897
pmcid: 6712480
doi: 10.1002/cam4.2360
Jin, H. et al. N(6)-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancer. EBioMedicine 47, 195–207 (2019).
pubmed: 31409574
pmcid: 6796523
doi: 10.1016/j.ebiom.2019.07.068
Thakkar, J. P. et al. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol. Biomark. Prev. 23, 1985–1996 (2014).
doi: 10.1158/1055-9965.EPI-14-0275
Zhang, S. et al. m(6)A demethylase ALKBH5 maintains tumorigenicity of glioblastoma stem-like cells by sustaining FOXM1 expression and cell proliferation program. Cancer Cell 31, 591–606 e596 (2017).
pubmed: 28344040
pmcid: 5427719
doi: 10.1016/j.ccell.2017.02.013
Lathia, J. D., Mack, S. C., Mulkearns-Hubert, E. E., Valentim, C. L. & Rich, J. N. Cancer stem cells in glioblastoma. Genes Dev. 29, 1203–1217 (2015).
pubmed: 26109046
pmcid: 4495393
doi: 10.1101/gad.261982.115
Cui, Q. et al. m(6)A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Rep. 18, 2622–2634 (2017).
pubmed: 28297667
pmcid: 5479356
doi: 10.1016/j.celrep.2017.02.059
Visvanathan, A. et al. Essential role of METTL3-mediated m(6)A modification in glioma stem-like cells maintenance and radioresistance. Oncogene 37, 522–533 (2018).
pubmed: 28991227
doi: 10.1038/onc.2017.351
Li, T. et al. METTL3 facilitates tumor progression via an m(6)A-IGF2BP2-dependent mechanism in colorectal carcinoma. Mol. Cancer 18, 112 (2019).
pubmed: 31230592
pmcid: 6589893
doi: 10.1186/s12943-019-1038-7
Nishizawa, Y. et al. Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer. Oncotarget 9, 11 (2017).
Li, X. et al. The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinoma. Oncotarget 8, 14 (2017).
Liu, J. et al. m(6)A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat. Cell Biol. 20, 1074–1083 (2018).
pubmed: 30154548
pmcid: 6245953
doi: 10.1038/s41556-018-0174-4
Wang, X. et al. Reduced m6A mRNA methylation is correlated with the progression of human cervical cancer. Oncotarget 8, 13 (2017).
Chen, J. et al. YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. Cell Cycle 16, 2259–2271 (2017).
pubmed: 29135329
pmcid: 5788481
doi: 10.1080/15384101.2017.1380125