An extremely rare case of nivolumab-associated macroscopic duodenitis with spontaneous regression.
Duodenitis
immune‐related adverse events
nivolumab
spontaneous regression
Journal
Respirology case reports
ISSN: 2051-3380
Titre abrégé: Respirol Case Rep
Pays: United States
ID NLM: 101631052
Informations de publication
Date de publication:
Jul 2020
Jul 2020
Historique:
received:
31
03
2020
revised:
21
04
2020
accepted:
27
04
2020
entrez:
15
5
2020
pubmed:
15
5
2020
medline:
15
5
2020
Statut:
epublish
Résumé
An 82-year-old man was presented to our hospital due to epigastric and right hypochondrial pain 17 weeks after the initiation of intravenous treatment with nivolumab for recurrent lung adenocarcinoma as multiple lung and sternal metastases. Urgent gastroscopy revealed macroscopic duodenitis such as severe erythema, oedema, black-coloured erosions, and ulcers located throughout the second portion of the duodenum, which was confirmed by abdominal computed tomography as circumferential thickening of the duodenal wall. Those lesions were pathologically considered as non-specific inflammation and spontaneously disappeared within a month, suggesting nivolumab-induced immune-related adverse events.
Identifiants
pubmed: 32405415
doi: 10.1002/rcr2.582
pii: RCR2582
pmc: PMC7214783
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e00582Informations de copyright
© 2020 The Authors. Respirology Case Reports published by John Wiley & Sons Australia, Ltd on behalf of The Asian Pacific Society of Respirology.
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