Method for the synthesis of flavonoid nitrogen mustard derivatives.
Chlorination
Organic synthesis
Yield
Journal
MethodsX
ISSN: 2215-0161
Titre abrégé: MethodsX
Pays: Netherlands
ID NLM: 101639829
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
02
2020
accepted:
19
04
2020
entrez:
15
5
2020
pubmed:
15
5
2020
medline:
15
5
2020
Statut:
epublish
Résumé
We have prepared a kind of new type of flavonoid nitrogen mustard derivatives with broad-spectrum antitumor activity, which have not been reported in the literature. In the process of preparing intermediate (the flavonoid diethanolamine derivatives) of the target compound, we found that the reasonable separation method is silica gel column chromatography with eluent (MeOH/CH
Identifiants
pubmed: 32405467
doi: 10.1016/j.mex.2020.100903
pii: S2215-0161(20)30122-9
pii: 100903
pmc: PMC7210452
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100903Informations de copyright
© 2020 The Authors.
Références
Steroids. 2017 Jul;123:73-83
pubmed: 28450070
Eur J Med Chem. 2018 Feb 25;146:588-598
pubmed: 29407983
Eur J Med Chem. 2018 Oct 5;158:493-501
pubmed: 30243153
Eur J Med Chem. 2017 Feb 15;127:87-99
pubmed: 28038329
Bioorg Chem. 2020 Mar;96:103613
pubmed: 32028061
Bioorg Med Chem Lett. 2019 May 1;29(9):1120-1126
pubmed: 30846253