Associations between the Neutrophil-to-Lymphocyte Ratio and Diabetic Complications in Adults with Diabetes: A Cross-Sectional Study.
Journal
Journal of diabetes research
ISSN: 2314-6753
Titre abrégé: J Diabetes Res
Pays: England
ID NLM: 101605237
Informations de publication
Date de publication:
2020
2020
Historique:
received:
18
12
2019
revised:
07
04
2020
accepted:
15
04
2020
entrez:
15
5
2020
pubmed:
15
5
2020
medline:
19
3
2021
Statut:
epublish
Résumé
The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive and easily measurable laboratory index indicating systemic inflammation, while the application of many other inflammatory markers has been limited in daily clinical practice. However, large population studies about investigating the associations of the NLR level with diabetic complications including cardiovascular and cerebrovascular diseases (CVD), diabetic kidney disease (DKD), and diabetic retinopathy (DR) in the same population were limited. The aim of our study is to evaluate the associations between the NLR level and the prevalence of CVD, DKD, and DR in adults with diabetes simultaneously. A cross-sectional survey of 4,813 diabetic adults was conducted in seven communities in China. Persons underwent several medical examinations, including the measurement of anthropometric factors, blood pressure, routinely analyzed leukocyte characteristics, glucose, lipid profiles, urine albumin/creatinine ratio, and fundus photographs. Compared with the first quartile of the NLR level, the odds of having CVD was significantly increased by 21% for participants in the highest quartile (OR 1.21; 95% CI 1.00, 1.47) ( A higher NLR level was associated with an increased prevalence of CVD and DKD, other than DR, in diabetic adults.
Identifiants
pubmed: 32405503
doi: 10.1155/2020/6219545
pmc: PMC7206875
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6219545Informations de copyright
Copyright © 2020 Heng Wan et al.
Déclaration de conflit d'intérêts
The authors declare that they have no competing or financial interests regarding to the submitted work.
Références
Pharmacotherapy. 2003 Sep;23(9 Pt 2):26S-33S
pubmed: 14524636
Am J Cardiol. 2008 Sep 15;102(6):653-7
pubmed: 18773982
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
Diabetes Metab Res Rev. 2013 Mar;29(3):220-6
pubmed: 23280928
Invest Ophthalmol Vis Sci. 2011 Sep 29;52(10):7697-703
pubmed: 21873679
Exp Clin Endocrinol Diabetes. 2019 Apr;127(4):189-194
pubmed: 29421824
Diabetes Metab Res Rev. 2016 Jul;32(5):440-1
pubmed: 27464264
Exp Clin Endocrinol Diabetes. 2015 May;123(5):267-71
pubmed: 25853704
Eur J Immunol. 1975 May;5(5):330-6
pubmed: 1086234
Diabetes Metab. 2015 Sep;41(4):304-311
pubmed: 25656745
Front Endocrinol (Lausanne). 2013 Aug 21;4:105
pubmed: 23970880
J Clin Endocrinol Metab. 2016 May;101(5):2218-25
pubmed: 27003304
Am J Cardiol. 2010 Jan 15;105(2):186-91
pubmed: 20102916
Eur J Prev Cardiol. 2016 Jul;23(11):1211-20
pubmed: 26643521
Nat Rev Endocrinol. 2018 Feb;14(2):88-98
pubmed: 29219149
Ophthalmology. 2003 Sep;110(9):1677-82
pubmed: 13129861
Circulation. 2002 Jun 18;105(24):2872-7
pubmed: 12070116
Diabetes Res Clin Pract. 2017 Aug;130:90-97
pubmed: 28582723
Diabetes Care. 2018 May;41(5):971-978
pubmed: 29348194
Diabetes Care. 2019 Jan;42(Suppl 1):S124-S138
pubmed: 30559237
Atherosclerosis. 1997 May;131(1):79-84
pubmed: 9180248
Diabetes Technol Ther. 2014 Aug;16(8):524-30
pubmed: 24455985
Atherosclerosis. 2013 May;228(1):203-10
pubmed: 23489347
Diabetes Res Clin Pract. 2020 Feb;160:108005
pubmed: 31911248
Diabetes Res Clin Pract. 2018 Oct;144:118-125
pubmed: 30176260
Endocr Pract. 2019 Aug;25(8):809-816
pubmed: 31013151
Diabetes Metab. 2020 Feb;46(1):33-40
pubmed: 31026551
Cardiol J. 2014;21(5):500-8
pubmed: 24142685
Diabetes Res Clin Pract. 2018 Apr;138:271-281
pubmed: 29496507
Endocr Pract. 2019 Jan;25(1):69-100
pubmed: 30742570
Indian J Endocrinol Metab. 2017 May-Jun;21(3):387-392
pubmed: 28553592
JAMA. 2013 Sep 4;310(9):948-59
pubmed: 24002281
Int Urol Nephrol. 2019 Jul;51(7):1239-1247
pubmed: 31089947
N Engl J Med. 1997 Aug 21;337(8):516-22
pubmed: 9262494
J Am Heart Assoc. 2013 Apr 08;2(2):e000087
pubmed: 23568342
Clin Endocrinol (Oxf). 2015 Feb;82(2):229-33
pubmed: 25088518
Circulation. 2004 Mar 9;109(9):1089-94
pubmed: 14993130
Clin Nutr. 2017 Feb;36(1):253-259
pubmed: 26646357