Protocol and recruitment results from a 13-week randomized controlled trial comparing the effects of different doses of nitrate-rich beetroot juice on cognition, cerebral blood flow and peripheral vascular function in overweight and obese older people.
Beetroot juice
Blood pressure
Cerebral blood flow
Cognition
Inorganic nitrate
Older adults
Journal
Contemporary clinical trials communications
ISSN: 2451-8654
Titre abrégé: Contemp Clin Trials Commun
Pays: Netherlands
ID NLM: 101671157
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
24
12
2019
revised:
11
03
2020
accepted:
19
04
2020
entrez:
15
5
2020
pubmed:
15
5
2020
medline:
15
5
2020
Statut:
epublish
Résumé
Nitrate-rich food can increase NO production and may induce positive effects on brain function. This study examined the feasibility of a randomized clinical trial (RCT) testing the effects of prolonged consumption of incremental doses of dietary nitrate (NO This was a single blind, four-arm parallel RCT conducted in 60 overweight and obese older participants. Eligible participants were randomized to:1) high NO Participant recruitment started in July 2018 and ended in April 2019. Of all the recruitment strategies that were used, advertisement of the study via Facebook generated the highest response rate. Sixty-two participants consented and were enrolled. Overall, characteristics of included participants matched our recruitment criteria. The findings from this study provide evidence of the acceptability and feasibility of an intervention investigating the effects of incremental doses of high-nitrate BJ over a prolonged period. The intervention study was registered with clinical trial ISRCTN registry (ISRCTN14746723) on 27 December 2018.
Sections du résumé
BACKGROUND
BACKGROUND
Nitrate-rich food can increase NO production and may induce positive effects on brain function. This study examined the feasibility of a randomized clinical trial (RCT) testing the effects of prolonged consumption of incremental doses of dietary nitrate (NO
METHODS
METHODS
This was a single blind, four-arm parallel RCT conducted in 60 overweight and obese older participants. Eligible participants were randomized to:1) high NO
RESULTS
RESULTS
Participant recruitment started in July 2018 and ended in April 2019. Of all the recruitment strategies that were used, advertisement of the study via Facebook generated the highest response rate. Sixty-two participants consented and were enrolled. Overall, characteristics of included participants matched our recruitment criteria.
CONCLUSION
CONCLUSIONS
The findings from this study provide evidence of the acceptability and feasibility of an intervention investigating the effects of incremental doses of high-nitrate BJ over a prolonged period.
TRIAL REGISTRATION
BACKGROUND
The intervention study was registered with clinical trial ISRCTN registry (ISRCTN14746723) on 27 December 2018.
Identifiants
pubmed: 32405570
doi: 10.1016/j.conctc.2020.100571
pii: S2451-8654(20)30055-7
pii: 100571
pmc: PMC7212182
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100571Subventions
Organisme : Medical Research Council
ID : MR/P020941/1
Pays : United Kingdom
Informations de copyright
© 2020 The Authors.
Déclaration de conflit d'intérêts
The authors have no conflict of interest to declare.
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