Smad3 gene C-terminal phosphorylation site mutation aggravates CCl
inflammation
liver
mutation
pSmad3C
Journal
Journal of cellular and molecular medicine
ISSN: 1582-4934
Titre abrégé: J Cell Mol Med
Pays: England
ID NLM: 101083777
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
16
07
2019
revised:
17
02
2020
accepted:
27
04
2020
pubmed:
15
5
2020
medline:
30
4
2021
entrez:
15
5
2020
Statut:
ppublish
Résumé
The expression of C-terminal phosphorylated Smad3 (pSmad3C) is down-regulated with the progression of liver disease. Thus, we hypothesized that pSmad3C expression may be negatively related to liver disease. To develop novel therapeutic strategies, a suitable animal model is required that will allow researchers to study the effect of Smad3 domain-specific phosphorylation on liver disease progression. The current study aimed to construct a new mouse model with the Smad3 C-terminal phosphorylation site mutation and to explore the effects of this mutation on CCl
Identifiants
pubmed: 32406200
doi: 10.1111/jcmm.15385
pmc: PMC7299733
doi:
Substances chimiques
Smad3 Protein
0
Carbon Tetrachloride
CL2T97X0V0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7044-7054Informations de copyright
© 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.
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