An Inflammatory Profile Correlates With Decreased Frequency of Cytotoxic Cells in Coronavirus Disease 2019.
COVID-19
MDSC
NK cells
cytotoxic cells
inflammation
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
ISSN: 1537-6591
Titre abrégé: Clin Infect Dis
Pays: United States
ID NLM: 9203213
Informations de publication
Date de publication:
19 11 2020
19 11 2020
Historique:
received:
01
04
2020
accepted:
11
05
2020
pubmed:
15
5
2020
medline:
15
12
2020
entrez:
15
5
2020
Statut:
ppublish
Résumé
Increased production of inflammatory cytokines and myeloid-derived suppressor cells occurs in patients with coronavirus disease 2019. These inversely correlated with perforin-expressing natural killer (NK) and CD3+ T cells. We observed a lower number of perforin-expressing NK cells in intensive care unit (ICU) patients compared with non-ICU patients, suggesting an impairment of the immune cytotoxic arm as a pathogenic mechanism.
Identifiants
pubmed: 32407466
pii: 5837139
doi: 10.1093/cid/ciaa577
pmc: PMC7239202
doi:
Substances chimiques
Cytokines
0
Perforin
126465-35-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2272-2275Informations de copyright
© The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America.
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