Synthesis and trypanocidal activity of novel pyridinyl-1,3,4-thiadiazole derivatives.

Animals Chagas Disease / drug therapy Inhibitory Concentration 50 Mice Structure-Activity Relationship Thiadiazoles / chemical synthesis Trypanocidal Agents / chemical synthesis Trypanosoma cruzi / drug effects
1,3,4-thiadiazole-N-arylhydrazone 2-amino-1,3,4-thiadiazole Chagas disease Inhibitor of sterol biosynthesis Trypanocidal activity

Journal

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
ISSN: 1950-6007
Titre abrégé: Biomed Pharmacother
Pays: France
ID NLM: 8213295

Informations de publication

Date de publication:
Jul 2020
Historique:
received: 25 02 2020
revised: 08 04 2020
accepted: 13 04 2020
pubmed: 15 5 2020
medline: 12 2 2021
entrez: 15 5 2020
Statut: ppublish

Résumé

Herein, we present the design, synthesis and trypanocidal evaluation of sixteen new 1,3,4-thiadiazole derivatives from N-aminobenzyl or N-arylhydrazone series. All derivatives were assayed against the trypomastigote form of Trypanosoma cruzi, showing IC

Identifiants

DOI: 10.1016/j.biopha.2020.110162 PMID: 32407986
pubmed: 32407986
pii: S0753-3322(20)30354-1
doi: 10.1016/j.biopha.2020.110162
pii:
doi:

Substances chimiques

Thiadiazoles 0
Trypanocidal Agents 0
1,3,4-thiadiazole 14IAC3GH7G

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

110162

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Masson SAS.. All rights reserved.

Auteurs

Rosana H C N Freitas (RHCN)

Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 21941902, Rio de Janeiro, RJ, Brazil.

Juliana M C Barbosa (JMC)

Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-360, Rio de Janeiro, RJ, Brazil.

Patrícia Bernardino (P)

Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-360, Rio de Janeiro, RJ, Brazil.

Vitor Sueth-Santiago (V)

Instituto Federal de Educação, Ciência e Tecnologia do Rio de Janeiro, Campus São Gonçalo, 24425-004, São Gonçalo, RJ, Brazil.

Solange M S V Wardell (SMSV)

CHEMSOL, 1 Harcourt Road, Aberdeen, AB15 5NY, Scotland, UK.

James L Wardell (JL)

Department of Chemistry, University of Aberdeen, Old Aberdeen, AB 24 3 UE, Scotland, UK.

Débora Decoté-Ricardo (D)

Departamento de Microbiologia e Imunologia Veterinária, Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, 23890-000, Seropédica, RJ, Brazil.

Tatiana G Melo (TG)

Laboratório de Ultraestrutura Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-360, Rio de Janeiro, RJ, Brazil.

Edson F da Silva (EF)

Instituto de Tecnologia em Fármacos e Farmanguinhos, Fundação Oswaldo Cruz, 21041-250, Rio de Janeiro, RJ, Brazil; Escola de Ciência e Tecnologia, Universidade do Grande Rio, 25071-202, Duque de Caxias, RJ, Brazil.

Kelly Salomão (K)

Laboratório de Biologia Celular, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, 21040-360, Rio de Janeiro, RJ, Brazil.

Carlos A M Fraga (CAM)

Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio), Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, 21941902, Rio de Janeiro, RJ, Brazil. Electronic address: cmfraga@ccsdecania.ufrj.br.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Synthesis and trypanocidal activity of novel...
questionsmedicales.fr › Infection › Maladies vectorielles › Maladie de Chagas › Synthesis and trypanocidal activity of novel...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Concentration inhibitrice 50 › Synthesis and trypanocidal activity of novel...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Synthesis and trypanocidal activity of novel...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › Synthesis and trypanocidal activity of novel...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Thiazoles › Thiadiazoles › Synthesis and trypanocidal activity of novel...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Synthesis and trypanocidal activity of novel...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Synthesis and trypanocidal activity of novel...