Biochanin-A elicits relaxation in coronary artery of goat through different mechanisms.
Biochanin-A
Ca(v)1.2 channels
Coronary artery
Goat
K(V) channels
Journal
Research in veterinary science
ISSN: 1532-2661
Titre abrégé: Res Vet Sci
Pays: England
ID NLM: 0401300
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
12
03
2019
revised:
25
04
2020
accepted:
02
05
2020
pubmed:
15
5
2020
medline:
21
10
2020
entrez:
15
5
2020
Statut:
ppublish
Résumé
Flavonoids have shown beneficial effects in various disease conditions as reported by various previous studies. Biochanin-A is a flavonoid present in various plants in nature. Present investigation was done to assess the vasorelaxant potential of biochanin-A on isolated coronary artery of goat and its possible mechanism of action. Vascular reactivity experiments were done on circumflex coronary artery of goats using the tension experiments. Goat coronary arterial rings were relaxed with biochanin-A in concentration (0.1-100 μM)-dependent manner. Endothelium had no effect on biochanin-A-induced relaxation. Maximum relaxation induced by biochanin-A was 116.54 ± 12.21% in endothelium-intact artery and it was not significantly different with maximal relaxation (108.22 ± 1.88%) of endothelium-denuded vessel. L-NAME (100 μM) did not show any effect on biochanin-A-induced relaxation. TEA (BK
Identifiants
pubmed: 32408231
pii: S0034-5288(19)30235-8
doi: 10.1016/j.rvsc.2020.05.003
pii:
doi:
Substances chimiques
Vasodilator Agents
0
Genistein
DH2M523P0H
biochanin A
U13J6U390T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
206-214Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest None.