Tinidazole: Another Therapeutic Option for Syphilis?
Administration, Oral
Adolescent
Adult
Anti-Bacterial Agents
/ administration & dosage
Antitrichomonal Agents
/ administration & dosage
Female
Humans
Injections, Intramuscular
Male
Middle Aged
Penicillin G Benzathine
/ administration & dosage
Syphilis
/ complications
Tinidazole
/ administration & dosage
Trichomonas Vaginitis
/ drug therapy
Trichomonas vaginalis
/ drug effects
Young Adult
alternative treatment
penicillin
syphilis
tinidazole
Journal
Journal of clinical pharmacology
ISSN: 1552-4604
Titre abrégé: J Clin Pharmacol
Pays: England
ID NLM: 0366372
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
20
01
2020
accepted:
31
03
2020
pubmed:
15
5
2020
medline:
1
7
2021
entrez:
15
5
2020
Statut:
ppublish
Résumé
After the incidental observation of an almost complete resolution of maculopapular eruption in a patient having simultaneously secondary syphilis and trichomonas vaginalis infection, we extended the treatment with tinidazole (500 mg 4 times daily for 7 days) to 10 other early syphilis patients before the start of the conventional penicillin treatment. All patients showed marked improvement of their lesions in a few days. After the introduction of the conventional penicillin regimen, the lesions further improved and VDRL titers declined at least 4-fold within 6 months in all patients. Tinidazole is a 5-nitroimidazole derivative as well as metronidazole but with a longer plasma half-life. It is activated intracellularly by bacterial/parasitic enzymes to a redox cytotoxic intermediate that damages large protein molecules and inhibits repair and transcription of DNA affecting also the cell wall. With this action, tinidazole might also have a synergic action with penicillin and doxycycline, facilitating the entry of such drugs. It is possible that tinidazole has the same bactericidal action on spirochetes other than Borrelia, such as Treponema pallidum, explaining its rapid therapeutic action on the lesions of early syphilis. Whether this action could be confirmed by studies on larger series of patients, tinidazole might be considered in case of allergy to penicillin or other antibiotics usually prescribed in syphilis.
Substances chimiques
Anti-Bacterial Agents
0
Antitrichomonal Agents
0
Tinidazole
033KF7V46H
Penicillin G Benzathine
RIT82F58GK
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1185-1188Informations de copyright
© 2020, The American College of Clinical Pharmacology.
Références
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