Zinc as a Therapeutic Agent in Bone Regeneration.
bone biology
bone healing
bone regeneration
chondrocytes
osteoblasts
osteoclasts
osteogenesis
therapeutics
zinc
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
12 May 2020
12 May 2020
Historique:
received:
22
04
2020
revised:
03
05
2020
accepted:
08
05
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
epublish
Résumé
Zinc is an essential mineral that is required for normal skeletal growth and bone homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However, the cellular and molecular pathways through which zinc promotes bone growth, homeostasis, and regeneration are poorly understood. Zinc can positively affect chondrocyte and osteoblast functions, while inhibiting osteoclast activity, consistent with a beneficial role for zinc in bone homeostasis and regeneration. Based on the effects of zinc on skeletal cell populations and the role of zinc in skeletal growth, therapeutic approaches using zinc to improve bone regeneration are being developed. This review focuses on the role of zinc in bone growth, homeostasis, and regeneration while providing an overview of the existing studies that use zinc as a bone regeneration therapeutic.
Identifiants
pubmed: 32408474
pii: ma13102211
doi: 10.3390/ma13102211
pmc: PMC7287917
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR069044
Pays : United States
Organisme : NIH HHS
ID : NIH R01AR069044
Pays : United States
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