RNA-Binding Proteins in Acute Leukemias.
ALL
AML
CPSF6
IGF2BP
MSI2
RBM15-MKL1
RNA-binding protein
WT1
ZFP36
hematopoiesis
hnRNP K
nucleolin
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 May 2020
12 May 2020
Historique:
received:
21
04
2020
revised:
07
05
2020
accepted:
10
05
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
23
2
2021
Statut:
epublish
Résumé
Acute leukemias are genetic diseases caused by translocations or mutations, which dysregulate hematopoiesis towards malignant transformation. However, the molecular mode of action is highly versatile and ranges from direct transcriptional to post-transcriptional control, which includes RNA-binding proteins (RBPs) as crucial regulators of cell fate. RBPs coordinate RNA dynamics, including subcellular localization, translational efficiency and metabolism, by binding to their target messenger RNAs (mRNAs), thereby controlling the expression of the encoded proteins. In view of the growing interest in these regulators, this review summarizes recent research regarding the most influential RBPs relevant in acute leukemias in particular. The reported RBPs, either dysregulated or as components of fusion proteins, are described with respect to their functional domains, the pathways they affect, and clinical aspects associated with their dysregulation or altered functions.
Identifiants
pubmed: 32408494
pii: ijms21103409
doi: 10.3390/ijms21103409
pmc: PMC7279408
pii:
doi:
Substances chimiques
RNA, Messenger
0
RNA-Binding Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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