Stem Cell Clinical Trials in Spinal Cord Injury: A Brief Review of Studies in the United States.
clinical trial
spinal cord injury
stem cell transplant
Journal
Medicines (Basel, Switzerland)
ISSN: 2305-6320
Titre abrégé: Medicines (Basel)
Pays: Switzerland
ID NLM: 101671069
Informations de publication
Date de publication:
12 May 2020
12 May 2020
Historique:
received:
21
03
2020
revised:
08
05
2020
accepted:
08
05
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
epublish
Résumé
Although many therapeutic approaches have been attempted to treat spinal cord injury, cellular transplantation offers the greatest promise in reconstituting the architecture of the damaged cord. A literature review was conducted to search for clinical trials investigating stem cells as treatment for spinal cord injury in the United States. Overall, eight studies met inclusion criteria. Of the included studies, four were identified as being terminated, suspended, or not yet recruiting. Two studies were identified as currently recruiting, including one phase one trial evaluating stereotactic injections of human spinal cord-derived neural stem cells in patients with chronic spinal cord injuries, and one trial of transplantation of autologous bone marrow derived stem cells via paraspinal injections, intravenous injections, and intranasal placement. One study was identified as an active study, a phase one trial of intrathecal injection of 100 million autologous, ex-vivo expanded, adipose-derived mesenchymal stem cells. One trial that was listed as completed is a phase 1/2a, dose escalation study, investigating stereotactic injection of human embryonic stem cell derived oligodendrocyte progenitor cells. Although few significant publications have emerged to this point, current trial results are promising.
Sections du résumé
BACKGROUND
BACKGROUND
Although many therapeutic approaches have been attempted to treat spinal cord injury, cellular transplantation offers the greatest promise in reconstituting the architecture of the damaged cord.
METHODS
METHODS
A literature review was conducted to search for clinical trials investigating stem cells as treatment for spinal cord injury in the United States.
RESULTS
RESULTS
Overall, eight studies met inclusion criteria. Of the included studies, four were identified as being terminated, suspended, or not yet recruiting. Two studies were identified as currently recruiting, including one phase one trial evaluating stereotactic injections of human spinal cord-derived neural stem cells in patients with chronic spinal cord injuries, and one trial of transplantation of autologous bone marrow derived stem cells via paraspinal injections, intravenous injections, and intranasal placement. One study was identified as an active study, a phase one trial of intrathecal injection of 100 million autologous, ex-vivo expanded, adipose-derived mesenchymal stem cells. One trial that was listed as completed is a phase 1/2a, dose escalation study, investigating stereotactic injection of human embryonic stem cell derived oligodendrocyte progenitor cells.
CONCLUSIONS
CONCLUSIONS
Although few significant publications have emerged to this point, current trial results are promising.
Identifiants
pubmed: 32408562
pii: medicines7050027
doi: 10.3390/medicines7050027
pmc: PMC7281746
pii:
doi:
Types de publication
Journal Article
Langues
eng
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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