Can Circulating Cardiac Biomarkers Be Helpful in the Assessment of

LMNA NT-proBNP arrhythmic risk stratification biomarkers laminopathy malignant ventricular arrhythmia troponin T

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
12 May 2020
Historique:
received: 01 04 2020
revised: 27 04 2020
accepted: 08 05 2020
entrez: 16 5 2020
pubmed: 16 5 2020
medline: 16 5 2020
Statut: epublish

Résumé

Mutations in the lamin A/C gene are variably phenotypically expressed; however, it is unclear whether circulating cardiac biomarkers are helpful in the detection and risk assessment of cardiolaminopathies. We sought to assess (1) clinical characteristics including serum biomarkers: high sensitivity troponin T (hsTnT) and N-terminal prohormone brain natriuretic peptide (NT-proBNP) in clinically stable cardiolaminopathy patients, and (2) outcome among pathogenic/likely pathogenic lamin A/C gene (

Identifiants

pubmed: 32408651
pii: jcm9051443
doi: 10.3390/jcm9051443
pmc: PMC7290314
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Narodowe Centrum Badań i Rozwoju
ID : ERA-CVD DETECTIN-HF/2/2017
Organisme : Narodowym Centrum Nauki
ID : 2011/01/B/NZ4/03455
Organisme : National Institute of Cardiology, Warsaw, Poland
ID : 2.57/VII/03
Organisme : National Institute of Cardiology, Warsaw, Poland
ID : 2.18/II/08
Organisme : National Institute of Cardiology, Warsaw, Poland
ID : 2.10/II/10
Organisme : National Institute of Cardiology, Warsaw, Poland
ID : 2.56/II/14
Organisme : Komitet Badań Naukowych
ID : 0010/P05B/98/14

Déclaration de conflit d'intérêts

The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.

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Auteurs

Przemyslaw Chmielewski (P)

Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, 04-628 Warsaw, Poland.

Ewa Michalak (E)

Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, 04-628 Warsaw, Poland.

Ilona Kowalik (I)

Department of Coronary Artery Disease and Cardiac Rehabilitation, National Institute of Cardiology, 04-628 Warsaw, Poland.

Maria Franaszczyk (M)

Molecular Biology Laboratory, Department of Medical Biology, National Institute of Cardiology, 04-628 Warsaw, Poland.

Malgorzata Sobieszczanska-Malek (M)

Department of Heart Failure and Transplantology, National Institute of Cardiology, 04-628 Warsaw, Poland.

Grazyna Truszkowska (G)

Molecular Biology Laboratory, Department of Medical Biology, National Institute of Cardiology, 04-628 Warsaw, Poland.

Malgorzata Stepien-Wojno (M)

Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, 04-628 Warsaw, Poland.

Elzbieta Katarzyna Biernacka (EK)

Department of Congenital Heart Diseases, National Institute of Cardiology, 04-628 Warsaw, Poland.

Bogna Foss-Nieradko (B)

Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, 04-628 Warsaw, Poland.

Michal Lewandowski (M)

2nd Department of Arrhythmia, National Institute of Cardiology, 04-628 Warsaw, Poland.

Artur Oreziak (A)

1st Department of Arrhythmia, National Institute of Cardiology, 04-628 Warsaw, Poland.

Maria Bilinska (M)

1st Department of Arrhythmia, National Institute of Cardiology, 04-628 Warsaw, Poland.

Mariusz Kusmierczyk (M)

Department of Cardiac Surgery and Transplantology, National Institute of Cardiology, 04-628 Warsaw, Poland.

Frédérique Tesson (F)

Interdisciplinary School of Health Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada.

Jacek Grzybowski (J)

Department of Cardiomyopathy, National Institute of Cardiology, 04-628 Warsaw, Poland.

Tomasz Zielinski (T)

Department of Heart Failure and Transplantology, National Institute of Cardiology, 04-628 Warsaw, Poland.

Rafal Ploski (R)

Department of Medical Genetics, Medical University of Warsaw, 02-106 Warsaw, Poland.

Zofia T Bilinska (ZT)

Unit for Screening Studies in Inherited Cardiovascular Diseases, National Institute of Cardiology, 04-628 Warsaw, Poland.

Classifications MeSH