An Integrated Dialysis Pharmacometric (IDP) Model to Evaluate the Pharmacokinetics in Patients Undergoing Renal Replacement Therapy.
Acute Kidney Injury
/ therapy
Adsorption
Anti-Bacterial Agents
/ pharmacology
Computer Simulation
Database Management Systems
Doripenem
/ pharmacology
Drug Stability
Humans
Metabolic Clearance Rate
Models, Biological
Prospective Studies
Renal Dialysis
/ methods
Renal Replacement Therapy
Risk Assessment
Teicoplanin
/ pharmacokinetics
adsorption
doripenem
pharmacokinetics
renal replacement therapy
teicoplanin
Journal
Pharmaceutical research
ISSN: 1573-904X
Titre abrégé: Pharm Res
Pays: United States
ID NLM: 8406521
Informations de publication
Date de publication:
14 May 2020
14 May 2020
Historique:
received:
21
02
2020
accepted:
22
04
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
2
10
2020
Statut:
epublish
Résumé
Clearance via renal replacement therapy (RRT) can significantly alter the pharmacokinetic profile of drugs. The aim of this study was (i) to improve the use of clinical trial data and (ii) to provide a model that allows quantification of all aspects of drug elimination via RRT including adsorption to dialysis membranes and/or degradation of the drug in the dialysate. An integrated dialysis pharmacometric (IDP) model was developed to simultaneously incorporate all available RRT information. The sensitivity, accuracy and precision of the IDP model was compared to conventional approaches in clinical trial simulations and applied to clinical datasets of teicoplanin and doripenem. The IDP model was more accurate, precise and sensitive than conventional plasma-concentration-based approaches when estimating the clearance The IDP model allows accurate, precise and sensitive characterization of clearance
Identifiants
pubmed: 32409892
doi: 10.1007/s11095-020-02832-w
pii: 10.1007/s11095-020-02832-w
pmc: PMC7225193
doi:
Substances chimiques
Anti-Bacterial Agents
0
Teicoplanin
61036-62-2
Doripenem
BHV525JOBH
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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