A novel approach to intra-individual performance variability in ADHD.
Attention deficit hyperactivity disorder
Intra-individual variability
Methylphenidate
Journal
European child & adolescent psychiatry
ISSN: 1435-165X
Titre abrégé: Eur Child Adolesc Psychiatry
Pays: Germany
ID NLM: 9212296
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
received:
23
05
2019
accepted:
01
05
2020
pubmed:
16
5
2020
medline:
11
5
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
Patients with attention deficit/(hyperactivity) disorder (AD(H)D) show increased intra-individual variability (IIV) in behavioral performance. This likely reflects dopaminergic deficiencies. However, the precise performance profile across time and the pattern of fluctuations within it have not yet been considered, partly due to insufficient methods. Yet, such an analysis may yield important theory-based implications for clinical practice. Thus, in a case-control cross-sectional study, we introduce a new method to investigate performance fluctuations in patients with ADD (n = 76) and ADHD (n = 67) compared to healthy controls (n = 45) in a time estimation task. In addition, we also evaluate the effects of methylphenidate (MPH) treatment on this performance pattern in 29 patients with AD(H)D. Trial-by-trial differences in performance between healthy controls and patients with AD(H)D do not persist continuously over longer time periods. Periods during which no differences in performance between healthy controls and patients occur alternate with periods in which such differences are present. AD(H)D subtype and surprisingly also medication status does not affect this pattern. The presented findings likely reflect (phasic) deficiencies of the dopaminergic system in patients with AD(H)D which are not sufficiently ameliorated by first-line pharmacological treatment. The presented findings carry important clinical and scientific implications.
Identifiants
pubmed: 32410131
doi: 10.1007/s00787-020-01555-y
pii: 10.1007/s00787-020-01555-y
pmc: PMC8060200
doi:
Substances chimiques
Methylphenidate
207ZZ9QZ49
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
733-745Subventions
Organisme : Else Kröner-Fresenius-Stiftung
ID : 2016_A94
Organisme : Friede Springer Stiftung
ID : 033/2017
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