Sodium plays an important role in the absorption of intravesical fluid.
aquaporins
bladder
claudins
intravesical administration
osmolality
Journal
Lower urinary tract symptoms
ISSN: 1757-5672
Titre abrégé: Low Urin Tract Symptoms
Pays: Australia
ID NLM: 101506777
Informations de publication
Date de publication:
Jan 2021
Jan 2021
Historique:
received:
28
01
2020
revised:
08
04
2020
accepted:
19
04
2020
pubmed:
16
5
2020
medline:
7
10
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
To investigate the role of sodium in intravesical absorption of water in the bladder and the sodium pathway in the urothelium. Adult female Sprague-Dawley rats received either saline or a 5% glucose solution injection into their bladders. The changes in intravesical fluid volume; concentrations of sodium and chlorine and osmolality; and expression of aquaporin-2, epithelial sodium channel, and claudins were compared after 3 hours. Intravesical volume decreased significantly in the saline group compared to that in the 5% glucose solution group. The expression of claudin-3 and -6 was higher in the saline group than in the glucose group. There was a significant correlation between changes in the intravesical saline volume and the concentration of sodium and chlorine. Intravesical administration of amiloride did not affect changes in the fluid volume and concentration of sodium. The presence of sodium is important for the absorption of intravesical fluid through aquaporin-2 in the urinary bladders of rats. Claudin-3 and -6 may be associated with the transport of sodium through the bladder urothelium.
Substances chimiques
Aquaporin 2
0
Claudins
0
Sodium Channels
0
Chlorine
4R7X1O2820
Sodium
9NEZ333N27
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
177-182Subventions
Organisme : JSPS KAKENHI
ID : P17K11190
Informations de copyright
© 2020 John Wiley & Sons Australia, Ltd.
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