Severe Acute Flaccid Myelitis Associated With Enterovirus in Children: Two Phenotypes for Two Evolution Profiles?

EV-A71 EV-D68 children enterovirus myelitis

Journal

Frontiers in neurology
ISSN: 1664-2295
Titre abrégé: Front Neurol
Pays: Switzerland
ID NLM: 101546899

Informations de publication

Date de publication:
2020
Historique:
received: 20 01 2020
accepted: 07 04 2020
entrez: 16 5 2020
pubmed: 16 5 2020
medline: 16 5 2020
Statut: epublish

Résumé

Acute flaccid myelitis (AFM) is an acute paralysis syndrome defined by a specific inflammation of the anterior horn cells of the spinal cord. From 2014, worrying waves of life-threatening AFM consecutive to enterovirus infection (EV-D68 and EV-A71) have been reported. We describe 10 children displaying an AFM with an EV infection, the treatments performed and the 1 to 3-years follow-up. Two groups of patients were distinguished: 6 children ("

Identifiants

pubmed: 32411086
doi: 10.3389/fneur.2020.00343
pmc: PMC7198806
doi:

Types de publication

Journal Article

Langues

eng

Pagination

343

Informations de copyright

Copyright © 2020 Aubart, Gitiaux, Roux, Levy, Schuffenecker, Mirand, Bach, Moulin, Bergounioux, Leruez-Ville, Rozenberg, Sterlin, Musset, Antona, Boddaert, Zhang, Kossorotoff and Desguerre.

Références

PLoS One. 2016 Oct 31;11(10):e0162877
pubmed: 27798639
Euro Surveill. 2016 Nov 17;21(46):
pubmed: 27918268
Neurology. 1983 Nov;33(11):1444-52
pubmed: 6685237
N Engl J Med. 1999 Sep 23;341(13):936-42
pubmed: 10498488
Clin Infect Dis. 2018 Feb 10;66(5):653-664
pubmed: 29028962
Emerg Infect Dis. 2016 Aug;22(8):1387-94
pubmed: 27434186
Dev Med Child Neurol. 2019 Mar;61(3):376-380
pubmed: 30417347
J Child Neurol. 2019 Aug;34(9):511-516
pubmed: 31014167
AJNR Am J Neuroradiol. 2015 Feb;36(2):245-50
pubmed: 25414005
Clin Infect Dis. 2016 Sep 15;63(6):737-745
pubmed: 27318332
Arch Dis Child. 1980 Aug;55(8):583-8
pubmed: 6254449
J Infect Dis. 1974 Mar;129(3):304-9
pubmed: 4361245
Ann Neurol. 2016 Sep;80(3):326-38
pubmed: 27422805
J Hyg Epidemiol Microbiol Immunol. 1979;23(3):284-95
pubmed: 231067
Pediatr Infect Dis J. 2019 Jan;38(1):16-21
pubmed: 30234793
Clin Microbiol Infect. 2017 Nov;23(11):874-881
pubmed: 28344164
N Engl J Med. 1999 Sep 23;341(13):929-35
pubmed: 10498487
PLoS Pathog. 2017 Feb 23;13(2):e1006199
pubmed: 28231269
Nat Med. 2019 Nov;25(11):1748-1752
pubmed: 31636453
J Child Neurol. 2017 Mar;32(3):301-307
pubmed: 28193112
Eur J Paediatr Neurol. 2019 Mar;23(2):235-239
pubmed: 30670331

Auteurs

Melodie Aubart (M)

Department of Paediatric Neurology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.
INSERM 1163, Imagine Institute, Paris, France.

Cyril Gitiaux (C)

Department of Paediatric Neurophysiology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.
INSERM U955-Team 10, Department of Neurosciences, Mondor Biomedical Research Institute, Paris-Est University, Créteil, France.

Charles Joris Roux (CJ)

Department of Paediatric Radiology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.

Raphael Levy (R)

Department of Paediatric Radiology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.

Isabelle Schuffenecker (I)

Laboratory of Virology, National Reference Center for Enterovirus, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France.

Audrey Mirand (A)

Laboratory of Virology, National Reference Center for Enterovirus Associated Laboratory, CHU Clermont-Ferrand, Clermont-Ferrand, France.

Nathalie Bach (N)

Paediatric Department, CHU Caen-Normandie, Caen, France.

Florence Moulin (F)

Intensive Care Unit, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.

Jean Bergounioux (J)

Intensive Care Unit, CHU Raymond Poincaré, Paris Saclay University, AP-HP, Garches, France.

Marianne Leruez-Ville (M)

Laboratory of Virology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.

Flore Rozenberg (F)

Laboratory of Virology, Cochin Hospital, University of Paris, AP-HP, Paris, France.

Delphine Sterlin (D)

Laboratory of Immunology, Pitié-Salpétrière Hospital, Sorbonne University, AP-HP, Paris, France.

Lucile Musset (L)

Laboratory of Immunology, Pitié-Salpétrière Hospital, Sorbonne University, AP-HP, Paris, France.

Denise Antona (D)

Direction des maladies infectieuses, Santé publique France, Saint-Maurice, France.

Nathalie Boddaert (N)

INSERM U955-Team 10, Department of Neurosciences, Mondor Biomedical Research Institute, Paris-Est University, Créteil, France.
Department of Paediatric Radiology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.

Shen Ying Zhang (SY)

INSERM 1163, Imagine Institute, Paris, France.

Manoelle Kossorotoff (M)

Department of Paediatric Neurology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.

Isabelle Desguerre (I)

Department of Paediatric Neurology, Necker-Enfants malades Hospital, University of Paris, AP-HP, Paris, France.

Classifications MeSH