TTF-1 Positive Primary Small Cell Carcinoma of the Breast: A Case Report and Review of the Literature.
PDL-1
TTF-1
breast cancer
neuroendocrine cancer
small cell cancer
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
01
2020
accepted:
30
03
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
27
5
2021
Statut:
epublish
Résumé
Primary small cell carcinoma of the breast (SCCB) is a rare tumor subtype comprising <0.1% of all breast carcinomas. Here we present a case of thyroid transcription factor-1 (TTF-1) positive SCCB that recurred within 3 years of diagnosis in the lung and lymph nodes. Given the small number of cases, no clear guidelines exist on the appropriate management of patients with these aggressive tumors. We present a case study and review the current literature to highlight the knowledge gaps and needs of patients with these rare tumors. A 50-year-old premenopausal woman with no family history, presented with a palpable right breast mass. Biopsy was consistent with primary SCCB that was poorly differentiated, positive for synaptophysin and chromogranin and TTF-1 and presence of ductal carcinoma
Identifiants
pubmed: 32411090
doi: 10.3389/fendo.2020.00228
pmc: PMC7201766
doi:
Substances chimiques
DNA-Binding Proteins
0
TTF1 protein, human
0
Transcription Factors
0
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
228Informations de copyright
Copyright © 2020 Boutrid, Kassem, Tozbikian, Morgan, White, Shah, Vandeusen, Sardesai, Williams, Stover, Lustberg, Wesolowski, Pudavalli, Williams, Konda, Fortier, Carbone, Ramaswamy and Cherian.
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