The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients.
Journal
Dermatology research and practice
ISSN: 1687-6105
Titre abrégé: Dermatol Res Pract
Pays: Egypt
ID NLM: 101312803
Informations de publication
Date de publication:
2020
2020
Historique:
received:
13
01
2020
revised:
27
03
2020
accepted:
16
04
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
epublish
Résumé
Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment. In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients ( Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients. Alterations in lipid profile with a significant increase of ALT ( Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.
Sections du résumé
BACKGROUND
BACKGROUND
Acne is a common condition of pilosebaceous follicle especially among young. Clinically, the most used medication in the treatment of moderate to severe acne is oral isotretinoin. However, interindividual variability in therapeutic response to isotretinoin and many side effects such as musculoskeletal pain, headache, and alteration in lipid profile can be seen with this treatment.
AIM
OBJECTIVE
In this study, the effect of genetic polymorphisms, rs2241766 and rs1501299, of the adiponectin gene was investigated in relation to the side effects of isotretinoin-treated young adult acne patients (
METHODS
METHODS
Several biochemical parameters were measured at baseline and after treatments with isotretinoin. The ADIPOQ gene SNPs, rs2241766 and rs1501299, were genotyped in 230 patients.
RESULTS
RESULTS
Alterations in lipid profile with a significant increase of ALT (
CONCLUSIONS
CONCLUSIONS
Current findings showed that rs1501299 of the ADIPOQ gene might be associated with changes in HDL level in acne patients following treatment with isotretinoin.
Identifiants
pubmed: 32411191
doi: 10.1155/2020/3176521
pmc: PMC7206862
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3176521Informations de copyright
Copyright © 2020 Munir Garba et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
Références
Br J Dermatol. 2011 Aug;165(2):302-10
pubmed: 21466536
Cytokine. 2013 Oct;64(1):1-10
pubmed: 23850004
JAMA. 2017 Jan 10;317(2):213
pubmed: 28097353
J Biol Chem. 2011 Dec 30;286(52):44913-20
pubmed: 22039048
Oncotarget. 2017 May 31;8(31):51994-52005
pubmed: 28881706
J Clin Lab Anal. 2018 Sep;32(7):e22446
pubmed: 29633340
OMICS. 2017 Jun;21(6):340-351
pubmed: 28617663
J Biomed Biotechnol. 2010;2010:401537
pubmed: 20414354
Arch Dermatol Res. 2007 Dec;299(10):467-73
pubmed: 17710426
Int J Clin Pharmacol Ther. 2013 Aug;51(8):631-40
pubmed: 23782583
Cutis. 2014 Nov;94(5):234-8
pubmed: 25474452
J Pediatr. 2019 Jan;204:256-262.e3
pubmed: 30274928
Postepy Dermatol Alergol. 2016 Aug;33(4):294-9
pubmed: 27605902
Dermatology. 2015;230(1):70-4
pubmed: 25573071
Lifestyle Genom. 2018;11(2):80-89
pubmed: 30472712
Ther Adv Psychopharmacol. 2013 Aug;3(4):244-5
pubmed: 24167696
PLoS One. 2014 Apr 16;9(4):e95270
pubmed: 24740426
Dermatoendocrinol. 2009 May;1(3):162-9
pubmed: 20436884
Int J Dermatol. 1997 Nov;36(11):859-62
pubmed: 9427082
Obes Rev. 2013 Dec;14(12):939-49
pubmed: 23957239
Ann Nutr Metab. 2016;69(3-4):226-231
pubmed: 27915341
J Clin Aesthet Dermatol. 2014 Feb;7(2 Suppl):S3-S21
pubmed: 24688620
Inflammation. 2019 Feb;42(1):1-5
pubmed: 30073565
Exp Ther Med. 2014 Oct;8(4):1340-1344
pubmed: 25187851
Vasc Health Risk Manag. 2010 Mar 03;6:73-85
pubmed: 20234782
Turk J Med Sci. 2019 Feb 11;49(1):238-244
pubmed: 30761880
Dermatology. 2017;233(4):314-319
pubmed: 29190629
Zhonghua Fu Chan Ke Za Zhi. 2014 Oct;49(10):758-62
pubmed: 25537248
Sci Rep. 2017 Feb 09;7:41683
pubmed: 28181566
Ther Clin Risk Manag. 2018 May 23;14:949-954
pubmed: 29872305
Dermatoendocrinol. 2018 Jun 18;10(1):e1477902
pubmed: 30574262
Curr Ther Res Clin Exp. 2019 Feb 10;90:27-31
pubmed: 30828405
Int J Dermatol. 2019 Feb;58(2):218-220
pubmed: 30229883
Crit Care. 2011 Apr 20;15(2):221
pubmed: 21586104
J Dermatolog Treat. 2019 Dec;30(8):813-817
pubmed: 30836808
Dermatol Clin. 2019 Apr;37(2):195-203
pubmed: 30850042
J Dermatolog Treat. 2018 Nov;29(7):688-693
pubmed: 29460655
Oncol Lett. 2012 Jan;3(1):176-180
pubmed: 22740876
Atherosclerosis. 2010 Feb;208(2):412-20
pubmed: 20018283
Asian Pac J Cancer Prev. 2019 Jan 25;20(1):139-143
pubmed: 30678425
Dermatol Ther. 2015 May-Jun;28(3):151-7
pubmed: 25754162
Gene. 2018 Jul 1;662:118-122
pubmed: 29627525
Nutrition. 2019 Sep;65:44-49
pubmed: 31029921
Diabetol Metab Syndr. 2018 Jun 4;10:44
pubmed: 29991967
J Cosmet Dermatol. 2019 Feb;18(1):16-20
pubmed: 29460332
N Engl J Med. 2019 Jan 10;380(2):199
pubmed: 30628426
J Family Med Prim Care. 2018 Jan-Feb;7(1):171-174
pubmed: 29915754