Extracellular Vesicles Involvement in the Modulation of the Glioblastoma Environment.
Journal
Journal of oncology
ISSN: 1687-8450
Titre abrégé: J Oncol
Pays: Egypt
ID NLM: 101496537
Informations de publication
Date de publication:
2020
2020
Historique:
received:
30
05
2019
accepted:
11
08
2019
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
epublish
Résumé
Glioblastoma (GBM) is the most deadly primary brain tumour and is a paradigmatic example of heterogeneous cancer. Although expanding data propose the phenotypic plasticity exhibited by glioblastoma cells, as a critical feature involved in the tumour development and posttherapy recurrence, the central machinery responsible for their aggressiveness remains elusive. Despite decades of research, the complex biology of the glioblastoma is still unknown. Progress in genetic and epigenetic discoveries has improved diagnostic classification, prognostic information, and therapeutic planning. In the complex model of intercellular signalling, several studies have shown that extracellular vesicles have a key role in the intercellular communication among GBM cells and the tumour microenvironment modulation. The purpose of this review is to summarize the role of the EV-mediated intercellular crosstalk in the glioblastoma physiopathology.
Identifiants
pubmed: 32411235
doi: 10.1155/2020/3961735
pmc: PMC7204270
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
3961735Informations de copyright
Copyright © 2020 Fausta Ciccocioppo et al.
Déclaration de conflit d'intérêts
The authors have no conflicts of interest to declare.
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