Biomarkers for Diagnosis and Prediction of Outcomes in Contrast-Induced Nephropathy.
Journal
International journal of nephrology
ISSN: 2090-214X
Titre abrégé: Int J Nephrol
Pays: United States
ID NLM: 101546753
Informations de publication
Date de publication:
2020
2020
Historique:
received:
22
08
2019
revised:
29
11
2019
accepted:
03
01
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
epublish
Résumé
Serum creatinine is suboptimal as a biomarker in the early diagnosis of contrast-induced nephropathy (CIN). In this study, we investigated a panel of novel biomarkers in the early diagnosis of CIN and in assessing patient outcomes. This single-centre, nested, prospective case-controlled study included 30 patients with CIN and 60 matched controls. Serum and urine samples were collected before contrast administration and at 24 hours, 48 hours, and ≥5 days after contrast administration. Concentrations of NGAL, cystatin C, Median serum levels for 24 h cystatin C ( Serum cystatin C at 24 h was the best biomarker for CIN diagnosis, while baseline levels of serum IL18,
Sections du résumé
BACKGROUND
BACKGROUND
Serum creatinine is suboptimal as a biomarker in the early diagnosis of contrast-induced nephropathy (CIN). In this study, we investigated a panel of novel biomarkers in the early diagnosis of CIN and in assessing patient outcomes.
METHODS
METHODS
This single-centre, nested, prospective case-controlled study included 30 patients with CIN and 60 matched controls. Serum and urine samples were collected before contrast administration and at 24 hours, 48 hours, and ≥5 days after contrast administration. Concentrations of NGAL, cystatin C,
RESULTS
RESULTS
Median serum levels for 24 h cystatin C (
CONCLUSION
CONCLUSIONS
Serum cystatin C at 24 h was the best biomarker for CIN diagnosis, while baseline levels of serum IL18,
Identifiants
pubmed: 32411464
doi: 10.1155/2020/8568139
pmc: PMC7204140
doi:
Types de publication
Journal Article
Langues
eng
Pagination
8568139Informations de copyright
Copyright © 2020 Justor Banda et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.
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