Three cases of severe adolescent asthma treated with mepolizumab: lung function trajectories.
Adolescent
Eosinophil count
Eosinophilic inflammation
Interleukin-5
Mepolizumab
Severe asthma
Journal
Asia Pacific allergy
ISSN: 2233-8276
Titre abrégé: Asia Pac Allergy
Pays: Netherlands
ID NLM: 101561954
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
17
12
2019
accepted:
02
04
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
epublish
Résumé
Real-world experience with mepolizumab for pediatric asthma is still limited. We report 3 patients who were treated with mepolizumab for severe adolescent asthma. Two patients, a 12-year-old boy and a 14-year-old girl, responded well to mepolizumab and showed apparent improvement in lung function from a downward trend over time before treatment. The third patient, a 16-year-old boy, whose treatment was switched from omalizumab to mepolizumab, did not have satisfactory response. The 2 successful cases had eosinophil counts of 440 and 371/μL and multiple comorbid allergic diseases including food allergies. The clinical benefit to them included elimination of both exacerbation and exercise-induced asthma. Interestingly, the boy's food-induced gastrointestinal symptoms disappeared following start of mepolizumab treatment.
Identifiants
pubmed: 32411578
doi: 10.5415/apallergy.2020.10.e13
pmc: PMC7203436
doi:
Types de publication
Case Reports
Langues
eng
Pagination
e13Informations de copyright
Copyright © 2020. Asia Pacific Association of Allergy, Asthma and Clinical Immunology.
Déclaration de conflit d'intérêts
Conflict of Interest: The authors have no financial conflicts of interest.
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