Ectopic ACTH Secretion in a Child With Metastatic Ewing's Sarcoma: A Case Report.
ACTH
Cushing Syndrome
Ewing's sarcoma
paraneoplastic syndrome
pediatric oncology
Journal
Frontiers in oncology
ISSN: 2234-943X
Titre abrégé: Front Oncol
Pays: Switzerland
ID NLM: 101568867
Informations de publication
Date de publication:
2020
2020
Historique:
received:
07
01
2020
accepted:
30
03
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
epublish
Résumé
Ectopic ACTH syndrome is rare in pediatric age. Sarcomas that cause Ectopic ACTH Syndrome (EAS) are even more uncommon. Currently, only three cases of EAS caused by Ewing' sarcoma have been reported. We detail a 10-year-old boy with Cushing's syndrome symptoms caused by ectopic ACTH production by a metastatic Ewing's sarcoma of the right ischio-pubic and ileo-pubic branches. The rapid appearance of cushingoid symptoms, with significant weight gain, acne, hirsutism, and hypercortisolism were implications of ectopic ACTH production as paraneoplastic Cushing's Syndrome. The very high levels of ACTH and non-suppression at the high dose dexamethasone test confirmed the clinical suspicion. We underline the possibility EAS was caused by an ACTH-secreting tumor, including soft tissue sarcomas.
Identifiants
pubmed: 32411598
doi: 10.3389/fonc.2020.00574
pmc: PMC7198717
doi:
Types de publication
Case Reports
Langues
eng
Pagination
574Informations de copyright
Copyright © 2020 Di Ruscio, Del Baldo, De Pasquale, De Vito, Miele, Colafati, Deodati, De Ioris, Tornesello, Milano and Mastronuzzi.
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