Metabolomic alterations associated with Kallmann syndrome.
Kallmann syndrome (KS)
biomarker
metabolomics
rare disease
Journal
Annals of translational medicine
ISSN: 2305-5839
Titre abrégé: Ann Transl Med
Pays: China
ID NLM: 101617978
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
16
5
2020
Statut:
ppublish
Résumé
This study was conducted to identify potential seminal plasma metabolic markers associated with disease activity in Kallmann syndrome (KS). We collected medical records and seminal plasma samples from 17 KS patients and 20 age-matched healthy controls (HC) and performed metabolomics analysis using the UPLC-QTOF-MS method. Partial least squares discriminant analysis (PLS-DA) showed that the metabolomics profile of KS patients was clearly separated from HC. Statistical analysis of the data indicates that there are differential metabolites between KS patients and HC. The main metabolic pathways focus on linoleic acid (LA) metabolism, Glycerophospholipid metabolism. The seminal plasma metabolomics profile of KS patients has changed. Glycerophospholipids and LA are promising biomarkers for KS diagnosis.
Sections du résumé
BACKGROUND
BACKGROUND
This study was conducted to identify potential seminal plasma metabolic markers associated with disease activity in Kallmann syndrome (KS).
METHODS
METHODS
We collected medical records and seminal plasma samples from 17 KS patients and 20 age-matched healthy controls (HC) and performed metabolomics analysis using the UPLC-QTOF-MS method.
RESULTS
RESULTS
Partial least squares discriminant analysis (PLS-DA) showed that the metabolomics profile of KS patients was clearly separated from HC. Statistical analysis of the data indicates that there are differential metabolites between KS patients and HC. The main metabolic pathways focus on linoleic acid (LA) metabolism, Glycerophospholipid metabolism.
CONCLUSIONS
CONCLUSIONS
The seminal plasma metabolomics profile of KS patients has changed. Glycerophospholipids and LA are promising biomarkers for KS diagnosis.
Identifiants
pubmed: 32411752
doi: 10.21037/atm.2020.04.03
pii: atm-08-08-529
pmc: PMC7214890
doi:
Types de publication
Journal Article
Langues
eng
Pagination
529Informations de copyright
2020 Annals of Translational Medicine. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at http://dx.doi.org/10.21037/atm.2020.04.03). The authors have no conflicts of interest to declare.
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