Effects of 3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one alone or/in association with cyclophosphamide on testicular function.
AMS35AA
cyclophosphamide
resorcinolic lipids
spermatogenesis
testis function
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
04
11
2019
revised:
06
02
2020
accepted:
04
04
2020
pubmed:
16
5
2020
medline:
22
6
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
Chemotherapy for cancer treatment may result in a temporary or long-term gonadal damage resulting in subfertility or infertility. Cyclophosphamide (CY) is a cytotoxic alkylating agent that has been widely used in the treatment of cancer. Recent studies have shown that synthetic resorcinol lipid AMS35AA (3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one) may be an important adjuvant chemotherapy that potentiates mutagenic damage and increases apoptosis caused by CY. The present study investigates the action of AMS35AA alone or/in association with CY on testicular function. Animals were divided into four groups: (a) control group: received only water; (b) CY group: received 150 μg/g of CY b.w., i.p.; (c) AMS35AA group: received 10 μg/g of AMS35AA b.w., i.p; and (d) associated group: received 10 μg/g of AMS35AA + 150 μg/g of CY b.w., i.p. Four weeks after the treatment, the results showed that testes weight of CY and associated groups decreased. However, the number of Sertoli cell and Leydig cell per testis was similar in control and treated groups. Our findings provide strong evidence that the AMS35AA alone or in CY association is not toxic to spermatogenesis. The absence of toxicity of AMS35AA supports the view that the resorcinolic lipid could be used associated with CY chemotherapy without causing adverse effects to testes function.
Substances chimiques
3-heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one
0
Benzofurans
0
Cyclophosphamide
8N3DW7272P
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13622Subventions
Organisme : Fundação de Amparo à Pesquisa do Estado de Minas Gerais
Organisme : Fundação de Apoio ao Desenvolvimento do Ensino, Ciência e Tecnologia do Estado de Mato Grosso do Sul
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 447433/2014-8
Informations de copyright
© 2020 Blackwell Verlag GmbH.
Références
Auharek, S. A., & França, L. (2010). Postnatal testis development, Sertoli cell proliferation and number of different spermatogonial types in C57BL ⁄6J mice made transiently hypo- and hyperthyroidic during the neonatal period. Journal of Anatomy, 216, 577-588. https://doi.org/10.1111/j.1469-7580.2010.01219.x
Auharek, S. A., Lara, N. L., Avelar, G. F., Sharpe, R. M., & França, L. R. (2012). Effects of inducible nitric oxide synthase (iNOS) deficiency in mice on Sertoli cell proliferation and perinatal testis development. International Journal of Andrology, 35, 741-751. https://doi.org/10.1111/j.1365-2605.2012.01264.x
Brady, S. F., Wagenaar, M. M., Singh, M. P., Janso, J. E., & Clardy, J. (2000). The cytosporones, new octaketide antibiotics isolated from an endophytic fungus. Organic Letters, 2(25), 4043-4046. https://doi.org/10.1021/ol006680s
Cai, L. U., Hales, B. F., & Robaire, B. (1997). Induction of apoptosis in the germ cells of adults male rats after exposure to cyclophosphamide. Biology of Reproduction, 56, 1490-1497.
Cao, Y., Wang, X., Shenqian, L. I., Wang Hongqiang, Y. L., & Wang, P. (2017). The effects of l-Carnitine aganst cyclophosphamide-induced injuries in mouse testis. Basic and Clinical Pharmacology and Toxicology, 120, 152-158.
Costa, D. S., Faria, F. J., Fernandes, C. A., Silva, J. C., & Auharek, S. A. (2013). Testis morphometry and kinetics of spermatogenesis in the feral pig (Sus scrofa). Animal Reproduction Science, 142, 63-70.
Drumond, A. L., Weng, C. C., Wang, G., Chiarini-Garcia, H., Eras-Garcia, L., & Meistrich, M. L. (2011). Effects of multiple doses of cyclophosphamide on mouse testes: Accessing the germ cells lost, and the functional damage of stem cells. Reproductive Toxicology, 32, 395-406. https://doi.org/10.1016/j.reprotox.2011.09.010
França, L. R., Avelar, G. F., & Almeida, F. F. L. (2005). Spermatogenesis and sperm transit through the epididymis in mammals with emphasis on pigs. Theriogenology, 63, 300-318. https://doi.org/10.1016/j.theriogenology.2004.09.014
França, L. R., & Godinho, C. L. (2003). Testis morphometry, seminiferous epithelium cycle length, and daily sperm production in domestic cats (Felis catus). Biology of Reproduction, 68, 1554-1561. https://doi.org/10.1095/biolreprod.102.010652
França, L. R., & Russell, L. D. (1998) The testis of domestic animals. In F. Martinez, & J. Regadera (Eds.), Male reproduction: A multidisciplinary overview (pp. 197-219) Madrid, Spain: Churchill Livingtone.
Goñi, F. M. (2014). The basic structure and dynamics of cell membranes: An update of the Singer-Nicolson model. Biochimica Et Biophysica Acta (BBA) - Biomembranes, 1838, 1467-1476. https://doi.org/10.1016/j.bbamem.2014.01.006
Hales, B. F. (1982). Comparison of the mutagenicity and teratogenicity of cyclophosphamide and its active metabolites, 4-hydroxycyclophosphamide, phosphoramide mustard and acrolein. Cancer Research, 42, 3016-3021.
Hess, R. A., & Franca, L. R. (2007). Spermatogenesis and cycle of the Seminiferous epithelium. In C. Y. Cheng (Ed.), Molecular mechanisms in spermatogenesis (pp. 1-15). Austin, TX: Landes Bioscience.
Hrapkiewicz, K., Medina, L., & Holmes, D. D. (1998). Clinical laboratory animal medicine: An introduction, (2nd ed., p. 277). Ames, IA: Iowa State University Press.
Hutchison, G. R., Scott, H. M., Walker, M., McKinnell, C., Ferrara, D., Mahood, I. K., & Sharpe, R. M. (2008). Sertoli cell development and function in an animal model of testicular dysgenesis syndrome. Biology of Reproduction, 78, 352-360.
Kehe, K., Balszuweit, F., Steinritz, D., & Theiermann, H. (2009). Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering. Toxicology, 263, 12-19.
Lu, C. C., & Meistrich, M. L. (1979). Cytotoxic effects of chemotherapeutic drugs on mouse testis cell. Cancer Research, 39, 3575-3582.
Makin, G., & Hickman, J. A. (2000). Apoptosis and cancer chemotherapy. Cell and Tissue Research 301, 143-152. https://doi.org/10.1007/s004419900160
Meistrich, M. L. (2009). Male gonadal toxicity. Pediatric Blood and Cancer, 53, 261-266. https://doi.org/10.1002/pbc.22004
Meistrich, M. L. (2013). Effects of chemotherapy and radiotherapy on spermatogenesis in humans. Fertility and Sterility, 100, 1180-1186.
Meistrich, M. L., Wilson, G., Brown, B. W., da Cunha, M. F., & Lipshultz, L. I. (1992). Impact of cyclophosphamide on long-term reduction in sperm count in men treated with combination chemotherapy for Ewing’s and soft tissue sarcomas. Cancer, 70, 2703-2712.
Navarro, S. D., Beatriz, A., Meza, A., Pesarine, J. R., Gomes, R. S. G., Karaziack, C. B., … Oliveira, R. J. (2014). A new synthetic resorcinolic lipid 3-Heptyl-3,4,6-trimethoxy-3H-isobenzofuran-1-one: Evaluation of toxicology and ability to potentiate the mutagenic and apoptotic effects of cyclophosphamide. European Journal of Medicinal Chemistry, 75, 132-142. https://doi.org/10.1016/j.ejmech.2014.01.057
Navarro, S. D., Pessatto, L. R., Meza, A., de Oliveira, E. J. T., Auharek, S. A., Vilela, L. C., … Martines, M. A. U. (2018). Life Science, 15(209), 300-312.
Oliveira, R. J., Navarro, S. D., de Lima, D. P., Mezza, A., Pesarine, J. R., Gomes, R. S., … Beatriz, A. (2015). A novel cytosporone 3-Heptyl-4,6-dihydroxy-3H-isobenzofuran-1-one: Synthesis; toxicological, apoptotic and immunomodulatory properties; and potentiation of mutagenic damage. BMC Cancer, 2-15. https://doi.org/10.1186/s12885-015-1532-2
Rasband, W. (2005). ImageJ. USA: National Institute of Health. Software in http://rsb.info.nih.gov/ij/
Russell, L. D., Ettlin, R. A., Sinha, H. A. P., & Clegg, E. D. (1990). Histological and histopatological evaluation of the testis, 1990 (286 p). Clearwater, FL: Cache River Press.
Sharpe, R. M. (1994). Regulation of spermatogenesis. In E. Knobil, & J. D. Neil (Eds.), The physiology of reproduction (pp. 1363-1434). New York, NY: Raven Press.
Shetty, G., & Meistrich, M. L. (2005). Hormonal approaches to preservation and restoration of male fertility after cancer treatment. Journal of the National Cancer Institute Monographs, 34, 36-39. https://doi.org/10.1093/jncimonographs/lgi002
Sprando, R. L. (1990). Perfusion of the testis through the heart using heparin. In L. D. Russell, R. A. Ettlin, H. A. P. Sinha, & E. D. Clegg (Eds.), Histological and histopathological evaluation of the testis (pp. 277-280) Clearwater, FL: Cache River Press.