Barrier lymphocytes in spondyloarthritis.
Journal
Current opinion in rheumatology
ISSN: 1531-6963
Titre abrégé: Curr Opin Rheumatol
Pays: United States
ID NLM: 9000851
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
pubmed:
16
5
2020
medline:
27
4
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
The clinical overlap between spondyloarthritis (SpA) and inflammation of barrier tissues such as the intestine and skin indicates a role of barrier tissue immunity in the development of SpA. Herein, we review the recent advances in understanding lymphocyte populations and functions within the intestine and skin implicated in the pathophysiology of SpA. A number of unique lymphocyte populations have been identified to be expanded within the gut and skin of patients with SpA, including γδ T cells, mucosa-associated invariant T (MAIT) cells, innate lymphoid cells (ILCs) and T resident memory (TRM) cells. These cells respond to microbial cues at their barrier surface causing cellular activation and generation of interleukin (IL)-17, which is hypothesized to be the mechanism by which they contribute to SpA pathogenesis. Understanding how unique lymphocyte populations expand and produce IL-17 in the development of SpA provides insights into the pathophysiology of this disease as well as potential future therapeutic avenues.
Identifiants
pubmed: 32412993
doi: 10.1097/BOR.0000000000000716
pii: 00002281-202007000-00004
pmc: PMC7871527
mid: NIHMS1668362
doi:
Substances chimiques
Interleukin-17
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
343-348Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK107905
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR075033
Pays : United States
Organisme : NIAMS NIH HHS
ID : T32 AR007534
Pays : United States
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