Comparison of Clinical Characteristics and Magnetic Resonance Imaging of Salivary Glands With Magnetic Resonance Sialography in Sjögren's Syndrome.


Journal

The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378

Informations de publication

Date de publication:
01 2021
Historique:
received: 27 12 2019
revised: 16 04 2020
accepted: 21 04 2020
pubmed: 16 5 2020
medline: 29 1 2021
entrez: 16 5 2020
Statut: ppublish

Résumé

To compare the results of magnetic resonance imaging with magnetic resonance sialography (MRSIAL) and the clinical and laboratory characteristics in a well-characterized cohort of patients with primary or secondary Sjögren's syndrome (SS) meeting the American-European Consensus Group criteria. Retrospective, observational, monocentric study. Thirty-six patients (81% female, mean age = 48 ± 35 years) with primary or secondary SS who underwent MRSIAL were included in the study. MRSIAL revealed characteristic radiological signs in the parotid, sublingual, and submandibular salivary glands in 35/36 patients (97%). Patients presenting with anti-Sjögren's syndrome-related antigen A (SSA) autoantibodies showed more often fatty infiltration, a "pepper-and-salt" appearance, ductal stenosis, and/or ductal dilation of the parotid gland (88%, 88%, and 72% respectively) than patients negative for anti-SSA (12%, 4%, and 28% respectively). MRSIAL demonstrated signs characteristic of SS in all 11 patients with negative minor salivary gland biopsy. For 15 patients undergoing ultrasound examination only, 11 (73%) had SS findings, but all 15 had SS findings on MRSIAL. Two cases of parotid lymphoma were detected by MRSIAL (6%). MRSIAL is a reliable technique to detect glandular anomalies in patients with SS, and seems to provide a valuable aid in the diagnosis of SS. 4 Laryngoscope, 131:E83-E89, 2021.

Identifiants

pubmed: 32413167
doi: 10.1002/lary.28742
doi:

Types de publication

Comparative Study Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

E83-E89

Informations de copyright

© 2020 The American Laryngological, Rhinological and Otological Society, Inc.

Références

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Auteurs

Raphaël André (R)

Department of Dermatology, Geneva University Hospitals, Geneva, Switzerland.
Department of Allergology and Clinical Immunology, Geneva University Hospitals, Geneva, Switzerland.

Minerva Becker (M)

Department of Radiology, Geneva University Hospitals, Geneva, Switzerland.

Tommaso Lombardi (T)

Department of Oral Medicine and Pathology, Geneva University Hospitals, Geneva, Switzerland.

Samanta Buchholzer (S)

Department of Maxillofacial Surgery, Geneva University Hospitals, Geneva, Switzerland.

Francis Marchal (F)

Department of Otorhinolaryngology-Head and Neck Surgery, Geneva University Hospitals, Geneva, Switzerland.

Jorg D Seebach (JD)

Department of Allergology and Clinical Immunology, Geneva University Hospitals, Geneva, Switzerland.

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