Art and Science of the Cellular Mesoscale.
cell function
cell structure
drug design
drug discovery
integrative structural biology
mesoscale modeling
molecular function
molecular structure
Journal
Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
30
12
2019
revised:
12
02
2020
accepted:
27
02
2020
entrez:
16
5
2020
pubmed:
16
5
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Experimental information from microscopy, structural biology, and bioinformatics may be integrated to build structural models of entire cells with molecular detail. This integrative modeling is challenging in several ways: the intrinsic complexity of biology results in models with many closely packed and heterogeneous components; the wealth of available experimental data is scattered among multiple resources and must be gathered, reconciled, and curated; and computational infrastructure is only now gaining the capability of modeling and visualizing systems of this complexity. We present recent efforts to address these challenges, both with artistic approaches to depicting the cellular mesoscale, and development and application of methods to build quantitative models.
Identifiants
pubmed: 32413324
pii: S0968-0004(20)30056-6
doi: 10.1016/j.tibs.2020.02.010
pmc: PMC7230070
mid: NIHMS1571815
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
472-483Subventions
Organisme : NIGMS NIH HHS
ID : P50 GM103368
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM069832
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM120604
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM133198
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
J Mol Graph. 1996 Feb;14(1):33-8, 27-8
pubmed: 8744570
Eurographics Workshop Vis Comput Biomed. 2015;2015:61-70
pubmed: 29291131
J Phys Chem B. 2018 May 31;122(21):5441-5447
pubmed: 29338247
Plant J. 2012 Apr;70(1):157-76
pubmed: 22449050
PLoS Biol. 2012 Jan;10(1):e1001244
pubmed: 22272186
Cell. 2006 Nov 17;127(4):831-46
pubmed: 17110340
Trends Biochem Sci. 2016 Nov;41(11):970-981
pubmed: 27669651
Protein Sci. 2018 Jan;27(1):14-25
pubmed: 28710774
Adv Chem Phys. 2014;155:1-68
pubmed: 25663722
PLoS Comput Biol. 2010 Mar 05;6(3):e1000694
pubmed: 20221255
PLoS Comput Biol. 2019 Jun 13;15(6):e1007150
pubmed: 31194731
Nat Methods. 2010 Mar;7(3 Suppl):S42-55
pubmed: 20195256
Science. 2015 Jan 23;347(6220):1260419
pubmed: 25613900
Annu Rev Biochem. 2008;77:443-77
pubmed: 18318657
Cell Biol Int. 2010 Nov;34(11):1105-7
pubmed: 20939832
Nucleic Acids Res. 2015 Jul 1;43(W1):W576-9
pubmed: 25925569
Cell. 2012 Jul 20;150(2):389-401
pubmed: 22817898
Comput Struct Biotechnol J. 2019 Jan 25;17:160-176
pubmed: 30788082
Science. 2017 May 26;356(6340):806-807
pubmed: 28546174
ACS Cent Sci. 2018 Nov 28;4(11):1570-1577
pubmed: 30555910
Nucleic Acids Res. 2017 Jul 27;45(13):7541-7554
pubmed: 28645155
Int Rev Cell Mol Biol. 2014;307:275-349
pubmed: 24380598
J Mol Biol. 2018 Oct 19;430(21):3954-3968
pubmed: 29885327
Biophys Rev. 2018 Apr;10(2):241-253
pubmed: 29235084
Cell. 2019 May 30;177(6):1384-1403
pubmed: 31150619
Science. 2014 May 30;344(6187):1023-8
pubmed: 24876496
Trends Mol Med. 2017 May;23(5):430-450
pubmed: 28416139
Curr Opin Struct Biol. 2019 Oct;58:149-158
pubmed: 31349128
J Mol Graph Model. 2015 May;58:1-9
pubmed: 25765281
Nat Chem Biol. 2009 Nov;5(11):774-7
pubmed: 19841622
Curr Opin Struct Biol. 2010 Apr;20(2):196-206
pubmed: 20167475
Cell. 2018 Mar 22;173(1):11-19
pubmed: 29570991
Nat Rev Chem. 2018 Apr;2(4):
pubmed: 30949587
Mol Biol Cell. 2014 Nov 5;25(22):3474-7
pubmed: 25368424
Nat Rev Microbiol. 2010 Aug;8(8):600-7
pubmed: 20634810
Nature. 2016 Jun 15;534(7608):570-4
pubmed: 27309814
Curr Opin Biotechnol. 2014 Aug;28:111-5
pubmed: 24556244
Trends Biochem Sci. 2001 Oct;26(10):597-604
pubmed: 11590012
Comput Graph Forum. 2019 Sep;38(6):150-164
pubmed: 31736528
J Am Chem Soc. 2018 Jan 10;140(1):200-210
pubmed: 29265822
J Comput Chem. 2015 Oct 5;36(26):1990-2008
pubmed: 26238484
Mol Cell Biochem. 1983;55(2):119-40
pubmed: 6633513
Trends Biochem Sci. 1991 Jun;16(6):203-6
pubmed: 1891800
Cell. 2016 Aug 25;166(5):1257-1268.e12
pubmed: 27565348
Annu Rev Cell Dev Biol. 2014;30:39-58
pubmed: 25288112
Nucleic Acids Res. 2018 May 4;46(8):3937-3952
pubmed: 29529244
Protein Sci. 2016 Nov;25(11):1911-1917
pubmed: 27503276
Structure. 2005 Mar;13(3):447-62
pubmed: 15766546
PLoS Biol. 2007 Dec;5(12):e308
pubmed: 18052608
Trends Cell Biol. 2015 Dec;25(12):719-722
pubmed: 26471224
Cell. 1982 Sep;30(2):345-7
pubmed: 6754085
J Phys Chem B. 2017 Apr 20;121(15):3871-3881
pubmed: 28291359
J Mol Biol. 2018 Oct 19;430(21):3969-3981
pubmed: 29752966
J Mol Biol. 2018 Oct 19;430(21):3997-4012
pubmed: 30009769
Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):32-7
pubmed: 10618366
Trends Biochem Sci. 2000 Mar;25(3):150-3
pubmed: 10694888
Autophagy. 2010 Jan;6(1):3-6
pubmed: 20023390
IEEE Comput Graph Appl. 2018 Nov-Dec;38(6):51-66
pubmed: 30668455
J Mol Biol. 2000 Dec 15;304(5):983-94
pubmed: 11124041
Annu Rev Cell Dev Biol. 2019 Oct 6;35:191-211
pubmed: 31299173
J Mol Biol. 2018 Oct 19;430(21):3982-3996
pubmed: 29964044
IEEE Trans Vis Comput Graph. 2018 Jan;24(1):862-872
pubmed: 28866533
Cell. 2019 Nov 14;179(5):1098-1111.e23
pubmed: 31730852
Nature. 2018 Mar 22;555(7697):475-482
pubmed: 29539637
J Am Chem Soc. 2019 Jul 3;141(26):10214-10224
pubmed: 31244184
J Mol Biol. 2016 Jul 31;428(15):2943-64
pubmed: 27255863
J Comput Chem. 2013 Jan 30;34(3):245-55
pubmed: 23007888
Nat Struct Mol Biol. 2017 Oct 5;24(10):800-808
pubmed: 28981073