Untangling Determinants of Enhanced Health and Lifespan through a Multi-omics Approach in Mice.
aging
calorie restriction
calories
dietary interventions
dietary restriction
fasting
meal fed
metabolism
metabolomics
time-restricted feeding
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
received:
17
05
2019
revised:
20
12
2019
accepted:
24
04
2020
pubmed:
16
5
2020
medline:
10
11
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
The impact of chronic caloric restriction (CR) on health and survival is complex with poorly understood underlying molecular mechanisms. A recent study in mice addressing the diets used in nonhuman primate CR studies found that while diet composition did not impact longevity, fasting time and total calorie intake were determinant for increased survival. Here, integrated analysis of physiological and multi-omics data from ad libitum, meal-fed, or CR animals was used to gain insight into pathways associated with improved health and survival. We identified a potential involvement of the glycine-serine-threonine metabolic axis in longevity and related molecular mechanisms. Direct comparison of the different feeding strategies unveiled a pattern of shared pathways of improved health that included short-chain fatty acids and essential PUFA metabolism. These findings were recapitulated in the serum metabolome from nonhuman primates. We propose that the pathways identified might be targeted for their potential role in healthy aging.
Identifiants
pubmed: 32413334
pii: S1550-4131(20)30235-7
doi: 10.1016/j.cmet.2020.04.018
pmc: PMC8214079
mid: NIHMS1712501
pii:
doi:
Substances chimiques
Fatty Acids, Unsaturated
0
Threonine
2ZD004190S
Serine
452VLY9402
Glucose
IY9XDZ35W2
Glycine
TE7660XO1C
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
100-116.e4Subventions
Organisme : NIA NIH HHS
ID : R01 AG040178
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AG000368
Pays : United States
Organisme : BLRD VA
ID : I01 BX003846
Pays : United States
Organisme : NIH HHS
ID : P51 OD011106
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG057408
Pays : United States
Informations de copyright
Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
Références
Ageing Res Rev. 2017 Oct;39:59-67
pubmed: 28017879
Cell Metab. 2019 Jan 8;29(1):221-228.e3
pubmed: 30197301
Trends Biochem Sci. 2016 Mar;41(3):231-244
pubmed: 26822488
J Gerontol A Biol Sci Med Sci. 2014 Aug;69(8):923-33
pubmed: 24201695
Cell Metab. 2019 Sep 3;30(3):573-593.e8
pubmed: 31353263
Cell Metab. 2014 Feb 4;19(2):181-92
pubmed: 24440038
Aging Cell. 2019 Feb;18(1):e12843
pubmed: 30334314
Physiol Behav. 2017 May 1;173:298-304
pubmed: 28242469
Nat Commun. 2017 Jan 17;8:14063
pubmed: 28094793
Cell Metab. 2019 Feb 5;29(2):303-319.e4
pubmed: 30174302
Science. 2009 Jul 10;325(5937):201-4
pubmed: 19590001
Arch Biochem Biophys. 2005 Jan 1;433(1):166-75
pubmed: 15581575
Nature. 2010 Mar 4;464(7285):121-5
pubmed: 20203611
Dev Cell. 2008 May;14(5):661-73
pubmed: 18477450
Int J Biochem Cell Biol. 2000 Mar;32(3):289-301
pubmed: 10716626
Cell Metab. 2016 Jun 14;23(6):1093-1112
pubmed: 27304509
Science. 2018 Nov 16;362(6416):770-775
pubmed: 30442801
Aging (Albany NY). 2017 Jul 31;9(7):1770-1824
pubmed: 28768896
Aging Cell. 2010 Feb;9(1):92-5
pubmed: 19878144
Curr Opin Clin Nutr Metab Care. 2018 Jul;21(4):260-266
pubmed: 29697540
Arch Biochem Biophys. 1994 Feb 1;308(2):413-9
pubmed: 7906505
PLoS One. 2011 Mar 31;6(3):e18450
pubmed: 21483791
Cell Metab. 2018 Sep 4;28(3):415-431.e4
pubmed: 30017356
Am J Physiol Endocrinol Metab. 2001 Dec;281(6):E1300-7
pubmed: 11701446
Trends Endocrinol Metab. 2012 Jul;23(7):319-25
pubmed: 22520961
Biochim Biophys Acta. 2010 Nov;1801(11):1175-83
pubmed: 20691280
J Lipid Res. 2009 Apr;50 Suppl:S52-6
pubmed: 18952572
Cell Metab. 2018 Aug 7;28(2):256-267.e5
pubmed: 29909969
Nature. 2012 Sep 13;489(7415):318-21
pubmed: 22932268
Aging Cell. 2017 Jun;16(3):529-540
pubmed: 28139067
Nature. 2009 Apr 23;458(7241):1056-60
pubmed: 19262508
Exp Gerontol. 2003 Mar;38(3):253-66
pubmed: 12581789
Cell Metab. 2018 Mar 6;27(3):559-571.e5
pubmed: 29456073
Exp Gerontol. 2010 Sep;45(9):691-701
pubmed: 20452416
Mol Genet Metab. 2017 Dec;122(4):145-152
pubmed: 29033250
Cell Metab. 2018 Mar 6;27(3):677-688.e5
pubmed: 29514073
J Biol Chem. 2005 Mar 25;280(12):10877-80
pubmed: 15642727
Exp Gerontol. 2003 Mar;38(3):267-78
pubmed: 12581790
Science. 2013 Jan 11;339(6116):222-6
pubmed: 23118012
Cell. 2010 Nov 24;143(5):802-12
pubmed: 21094524
J Gerontol A Biol Sci Med Sci. 2019 Jan 1;74(1):16-26
pubmed: 29718123
Science. 2009 May 1;324(5927):651-4
pubmed: 19299583
Cell Metab. 2016 Jun 14;23(6):1048-1059
pubmed: 27304506
Science. 2009 May 1;324(5927):654-7
pubmed: 19286518
Trends Endocrinol Metab. 2016 Jun;27(6):415-426
pubmed: 27113082
Ageing Res Rev. 2017 Oct;39:46-58
pubmed: 27810402
Prog Lipid Res. 2016 Oct;64:30-56
pubmed: 27496755
Proc Natl Acad Sci U S A. 2007 Jan 2;104(1):72-7
pubmed: 17185419
J Biol Chem. 2008 Oct 10;283(41):27628-27635
pubmed: 18687677
Cell Metab. 2014 Dec 2;20(6):991-1005
pubmed: 25470547
Mol Cell. 2013 Jan 10;49(1):186-99
pubmed: 23201123
Prostaglandins Leukot Essent Fatty Acids. 2006 Sep;75(3):161-8
pubmed: 16828546
Mol Cell Endocrinol. 2013 Feb 25;366(2):163-9
pubmed: 22750052
Cell Metab. 2018 Mar 6;27(3):657-666.e5
pubmed: 29478834
Cell. 2016 Sep 8;166(6):1371-1385
pubmed: 27610564
Nat Rev Endocrinol. 2017 Oct;13(10):572-587
pubmed: 28731034
J Cell Biol. 2016 Oct 10;215(1):15-25
pubmed: 27738003
Nutrients. 2017 Feb 10;9(2):
pubmed: 28208582
Cell Metab. 2014 Dec 2;20(6):1006-17
pubmed: 25470548
J Clin Invest. 2018 Jul 2;128(7):3144-3159
pubmed: 29911994
Methods Enzymol. 2009;459:493-519
pubmed: 19362652