Mechanism underlying cranial nerve rhizopathy.
Demyelination
Ectopic action potential
Hemifacial spasm
Hyperexcitability
Ion channels
Pathogenesis
Trigeminal neuralgia
Journal
Medical hypotheses
ISSN: 1532-2777
Titre abrégé: Med Hypotheses
Pays: United States
ID NLM: 7505668
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
03
03
2020
revised:
09
04
2020
accepted:
02
05
2020
pubmed:
16
5
2020
medline:
15
5
2021
entrez:
16
5
2020
Statut:
ppublish
Résumé
The cranial nerve rhizophathy, commonly presented with trigeminal neuralgia (TN) or hemifacial spasm (HFS), is a sort of hyperexcitability disorders with higher incidence in senior Asian. In this paper, a novel hypothesis on the pathogenesis is proposed and with which some clinical phenomena are explained. In those with crowded cerebellopontine angle in anatomy, the cranial nerve root and surrounding vessel are getting closer and closer to each other with aging and finally the neurovascular conflict happens. As the interfacial friction associated with pulse, the nerve incurs demyelination. Since this pathological change develops to a certain degree, some transmembrane proteins emerge from the nerve due to a series of signaling pathway mediated by inflammatory cytokines. Among them, voltage-gated (Na
Identifiants
pubmed: 32413700
pii: S0306-9877(20)30350-9
doi: 10.1016/j.mehy.2020.109801
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
109801Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.