Understanding the Pathophysiology of Cerebral Amyloid Angiopathy.
amyloid beta protein
biomarkers
cerebral amyloid angiopathy
dementia
neuroimaging
outcome
pathophysiology
small vessel disease
treatment
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 May 2020
13 May 2020
Historique:
received:
31
03
2020
revised:
04
05
2020
accepted:
08
05
2020
entrez:
17
5
2020
pubmed:
18
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Cerebral amyloid angiopathy (CAA), one of the main types of cerebral small vessel disease, is a major cause of spontaneous intracerebral haemorrhage and an important contributor to cognitive decline in elderly patients. Despite the number of experimental in vitro studies and animal models, the pathophysiology of CAA is still largely unknown. Although several pathogenic mechanisms including an unbalance between production and clearance of amyloid beta (Aβ) protein as well as 'the prion hypothesis' have been invoked as possible disease triggers, they do not explain completely the disease pathogenesis. This incomplete disease knowledge limits the implementation of treatments able to prevent or halt the clinical progression. The continuous increase of CAA patients makes imperative the development of suitable experimental in vitro or animal models to identify disease biomarkers and new pharmacological treatments that could be administered in the early disease stages to prevent irreversible changes and disease progression.
Identifiants
pubmed: 32414028
pii: ijms21103435
doi: 10.3390/ijms21103435
pmc: PMC7279405
pii:
doi:
Substances chimiques
Amyloid beta-Peptides
0
Biomarkers
0
Prion Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
J Clin Invest. 2012 Apr;122(4):1377-92
pubmed: 22406537
Mol Neurodegener. 2020 Mar 25;15(1):23
pubmed: 32213187
Neuroscience. 2016 May 13;322:28-38
pubmed: 26820600
Alzheimers Res Ther. 2019 May 13;11(1):44
pubmed: 31084613
Am J Pathol. 2005 Aug;167(2):505-15
pubmed: 16049335
J Neurosci. 2004 Jan 28;24(4):991-8
pubmed: 14749444
J Alzheimers Dis. 2016 Jun 13;53(3):893-905
pubmed: 27314529
Annu Rev Biochem. 1997;66:385-407
pubmed: 9242912
Neurosurg Focus. 2016 Jul;41(1):E10
pubmed: 27364252
Acta Neuropathol. 2009 Jul;118(1):115-30
pubmed: 19225789
Neurotox Res. 2016 Feb;29(2):256-66
pubmed: 26707129
Alzheimers Dement. 2015 Dec;11(12):1480-1488
pubmed: 26079413
Stroke. 2009 Mar;40(3 Suppl):S16-9
pubmed: 19064794
Arch Neurol. 2010 Dec;67(12):1491-7
pubmed: 21149810
J Biol Chem. 2010 Nov 19;285(47):36958-68
pubmed: 20847045
Int J Mol Sci. 2019 Sep 18;20(18):
pubmed: 31540372
Prion. 2017 Jul 4;11(4):215-225
pubmed: 28657440
J Biol Chem. 2011 Feb 18;286(7):5215-21
pubmed: 21118811
Transl Neurodegener. 2017 Aug 17;6:22
pubmed: 28824801
Acta Neuropathol Commun. 2017 Apr 4;5(1):26
pubmed: 28376923
Expert Rev Neurother. 2018 Jun;18(6):503-513
pubmed: 29792540
Acta Neuropathol. 2001 Dec;102(6):604-14
pubmed: 11761721
J Clin Invest. 2005 Nov;115(11):3285-90
pubmed: 16239972
J Biol Chem. 2010 Nov 19;285(47):36945-57
pubmed: 20739292
Genes Brain Behav. 2008 Feb;7 Suppl 1:67-82
pubmed: 18184371
Brain Behav. 2016 Nov 03;7(1):e00595
pubmed: 28127514
Ann Neurol. 2019 Feb;85(2):284-290
pubmed: 30597599
Neurobiol Aging. 2018 Oct;70:70-77
pubmed: 30007166
Acta Neuropathol. 2006 Oct;112(4):405-15
pubmed: 16865397
J Pineal Res. 2008 Sep;45(2):157-65
pubmed: 18298462
Alzheimers Res Ther. 2014 Jun 09;6(3):32
pubmed: 24991237
Mol Neurodegener. 2017 Aug 22;12(1):60
pubmed: 28830501
Front Aging Neurosci. 2019 Jul 04;11:172
pubmed: 31333445
Neurobiol Aging. 2002 May-Jun;23(3):405-12
pubmed: 11959403
J Neurol Sci. 2017 Oct 15;381:348-349
pubmed: 28947333
Stroke. 2018 Feb;49(2):491-497
pubmed: 29335334
Neurobiol Aging. 2000 Jan-Feb;21(1):27-30
pubmed: 10794845
Neurobiol Aging. 2017 Dec;60:116-128
pubmed: 28941727
J Neurochem. 2000 May;74(5):2209-12
pubmed: 10800967
J Neurosci Res. 2007 Oct;85(13):2917-23
pubmed: 17628026
Proc Natl Acad Sci U S A. 1999 Nov 23;96(24):14088-93
pubmed: 10570203
Neurobiol Aging. 2014 Mar;35(3):565-75
pubmed: 24138987
Front Neurol. 2019 Sep 27;10:966
pubmed: 31611836
Stroke. 2015 Jul;46(7):2032-60
pubmed: 26022637
Methods Mol Biol. 2012;814:235-49
pubmed: 22144311
Clin Sci (Lond). 2017 Sep 28;131(19):2469-2488
pubmed: 28963121
J Neurol Neurosurg Psychiatry. 2014 Mar;85(3):300-5
pubmed: 24163429
J Alzheimers Dis. 2011;23(3):375-89
pubmed: 21098977
Neurology. 2017 Jan 10;88(2):169-176
pubmed: 27903811
Acta Neuropathol Commun. 2018 Mar 5;6(1):23
pubmed: 29506560
Stroke. 2012 Feb;43(2):514-23
pubmed: 22116809
Biochim Biophys Acta. 2016 May;1862(5):1027-36
pubmed: 26454209
Acta Neuropathol Commun. 2018 Jan 8;6(1):5
pubmed: 29310723
Acta Neuropathol Commun. 2019 Jan 28;7(1):12
pubmed: 30691533
Proc Natl Acad Sci U S A. 2018 Jun 26;115(26):E5849-E5858
pubmed: 29895690
J Biol Chem. 2011 May 13;286(19):17217-26
pubmed: 21454574
J Clin Invest. 2000 Dec;106(12):1489-99
pubmed: 11120756
Hypertension. 2015 Jan;65(1):218-24
pubmed: 25331846
Stroke. 2010 Feb;41(2):394-6
pubmed: 20044530
J Alzheimers Dis. 2010;22(3):849-59
pubmed: 20858979
Ann Clin Transl Neurol. 2019 Mar 18;6(4):795-806
pubmed: 31020004
Brain. 2017 Jul 1;140(7):1829-1850
pubmed: 28334869
Ann Neurol. 2019 Oct;86(4):561-571
pubmed: 31359452
Neurobiol Aging. 2009 Feb;30(2):222-8
pubmed: 17673335
Nature. 2015 Sep 10;525(7568):247-50
pubmed: 26354483
Prog Mol Biol Transl Sci. 2019;168:223-241
pubmed: 31699317
J Neuropathol Exp Neurol. 2015 Sep;74(9):912-23
pubmed: 26247394
Nature. 2018 Dec;564(7736):415-419
pubmed: 30546139
Nature. 2014 Apr 3;508(7494):55-60
pubmed: 24670647
Acta Neuropathol Commun. 2019 Feb 26;7(1):26
pubmed: 30808415
Biochem Biophys Res Commun. 1984 Aug 16;122(3):1131-5
pubmed: 6236805
Neurobiol Dis. 2006 Sep;23(3):653-62
pubmed: 16829076
Biochim Biophys Acta. 2010 Apr;1804(4):986-95
pubmed: 20100601
Neuron. 2017 Sep 27;96(1):17-42
pubmed: 28957666
Cells. 2019 May 31;8(6):
pubmed: 31159306
J Alzheimers Dis. 2011;24(2):269-85
pubmed: 21239853
Sci Rep. 2017 Aug 14;7(1):8009
pubmed: 28808293
Curr Opin Lipidol. 2019 Jun;30(3):224-234
pubmed: 30946049
Nat Rev Genet. 2018 Jul;19(7):405-418
pubmed: 29713012
Nat Med. 2003 Jul;9(7):907-13
pubmed: 12808450
J Neurosci. 2001 Mar 1;21(5):1619-27
pubmed: 11222652
IUBMB Life. 2000 Oct-Nov;50(4-5):267-9
pubmed: 11327320
Antioxid Redox Signal. 2011 Sep 1;15(5):1167-78
pubmed: 21294650
Prion. 2014 Mar-Apr;8(2):
pubmed: 24549098
Science. 2006 Sep 22;313(5794):1781-4
pubmed: 16990547
Biochim Biophys Acta. 2016 May;1862(5):1037-46
pubmed: 26327684
J Dermatol Sci. 2014 May;74(2):150-8
pubmed: 24517869
BMC Med. 2017 Jan 25;15(1):16
pubmed: 28118831
Neurodegener Dis. 2012;10(1-4):329-31
pubmed: 22301467
J Cereb Blood Flow Metab. 2020 Feb;40(2):392-403
pubmed: 30614363
Brain Pathol. 2006 Jan;16(1):40-54
pubmed: 16612981
Nat Rev Mol Cell Biol. 2010 Apr;11(4):301-7
pubmed: 20308987
J Cereb Blood Flow Metab. 2020 Jan 27;:271678X19899377
pubmed: 31987010
Neurology. 1998 Apr;50(4):961-5
pubmed: 9566379
Neurology. 2018 Feb 27;90(9):e754-e762
pubmed: 29386280
FEBS Lett. 2003 Apr 10;540(1-3):181-7
pubmed: 12681505
J Cereb Blood Flow Metab. 2009 Jun;29(6):1079-83
pubmed: 19367293
J Neurochem. 2018 Mar;144(5):651-658
pubmed: 28833176
Science. 1996 Oct 4;274(5284):99-102
pubmed: 8810256
Nature. 2012 May 16;485(7399):512-6
pubmed: 22622580
Acta Neuropathol. 2018 Oct;136(4):569-587
pubmed: 29770843
Ann N Y Acad Sci. 1997 Sep 26;826:161-72
pubmed: 9329688
Neurology. 2019 Dec 10;93(24):e2192-e2202
pubmed: 31732564
Sci Rep. 2018 Feb 19;8(1):3269
pubmed: 29459625
Neuroscience. 2009 Mar 31;159(3):1055-69
pubmed: 19356689
Ann Clin Transl Neurol. 2014 Aug;1(8):519-33
pubmed: 25356424
Cell Metab. 2014 Apr 1;19(4):574-91
pubmed: 24508505
Brain. 2016 Feb;139(Pt 2):563-77
pubmed: 26493635
Brain Res Brain Res Rev. 2003 Oct;43(2):207-23
pubmed: 14572915
Acta Neuropathol. 2018 May;135(5):671-679
pubmed: 29450646
Neurol Sci. 2020 Mar 12;:
pubmed: 32166471
Am J Pathol. 2004 Sep;165(3):937-48
pubmed: 15331417
J Gerontol A Biol Sci Med Sci. 2010 May;65(5):559-64
pubmed: 20299544
Rev Neurosci. 2014;25(5):641-51
pubmed: 24870607
Acta Neuropathol Commun. 2019 May 2;7(1):70
pubmed: 31046829
Acta Neuropathol. 2018 May;135(5):801-803
pubmed: 29508058
JAMA. 2015 Sep 1;314(9):904-12
pubmed: 26325559
Nat Rev Immunol. 2013 Dec;13(12):888-902
pubmed: 24189576
Lancet Neurol. 2017 Feb;16(2):115-122
pubmed: 27989553
Arch Neurol. 2010 Aug;67(8):987-95
pubmed: 20697050
Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9735-40
pubmed: 10944232
J Neuroinflammation. 2017 Jun 5;14(1):114
pubmed: 28583195
J Am Heart Assoc. 2019 Feb 5;8(3):e011288
pubmed: 30717612
J Neurol Neurosurg Psychiatry. 2013 Aug;84(8):901-8
pubmed: 23457231
J Neurol Sci. 2017 Dec 15;383:11-17
pubmed: 29246595
Ann Neurol. 2011 Oct;70(4):532-40
pubmed: 22028219
Aging Cell. 2018 Jun;17(3):e12728
pubmed: 29453790
Neuron. 2012 Dec 6;76(5):871-85
pubmed: 23217737
Front Aging Neurosci. 2019 Jan 23;11:1
pubmed: 30740048
J Biol Chem. 2008 Dec 12;283(50):34554-62
pubmed: 18940800
J Neurosci. 2016 Feb 10;36(6):1930-41
pubmed: 26865616
Elife. 2017 Oct 10;6:
pubmed: 28994390
Nat Neurosci. 2004 Sep;7(9):954-60
pubmed: 15311281
Microvasc Res. 2008 Apr;75(3):411-9
pubmed: 18048067
Neurology. 2014 Jan 7;82(1):57-62
pubmed: 24285616
J Neuropathol Exp Neurol. 2000 Jan;59(1):29-38
pubmed: 10744033
Lancet Neurol. 2011 Aug;10(8):702-9
pubmed: 21741316
Acta Neuropathol. 2012 Mar;123(3):381-94
pubmed: 22170742
Nature. 1995 Feb 9;373(6514):523-7
pubmed: 7845465
Am J Pathol. 2000 Oct;157(4):1283-98
pubmed: 11021833
Biochim Biophys Acta. 2013 Aug;1834(8):1624-31
pubmed: 23608949
Ann Neurol. 2019 Oct;86(4):616-625
pubmed: 31361916
Brain Pathol. 2010 Jul;20(4):794-802
pubmed: 20175776
J Biol Chem. 2004 May 7;279(19):20296-306
pubmed: 14985348