Nanoliposomes from Agro-Resources as Promising Delivery Systems for Chondrocytes.
PUFA
chondrocyte
drug delivery system
joint regenerative medicine
liposomes
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 May 2020
13 May 2020
Historique:
received:
17
04
2020
revised:
05
05
2020
accepted:
11
05
2020
entrez:
17
5
2020
pubmed:
18
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially in rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due to their lipid bilayer structure similar to a biological membrane. Here we used natural rapeseed lecithin, which contains a high level of mono- and poly-unsaturated fatty acids, to evaluate the cytocompatibility of these phospholipids as future potential carriers of biomolecules in joint regenerative medicine. Results show that appropriate concentrations of nanoliposome rapeseed lecithin under 500 µg/mL were safe for chondrocytes and did not induce any alterations of their phenotype. Altogether, these results sustain that they could represent a novel natural carrier to deliver active substances into cartilage cells.
Identifiants
pubmed: 32414043
pii: ijms21103436
doi: 10.3390/ijms21103436
pmc: PMC7279141
pii:
doi:
Substances chimiques
Lecithins
0
Liposomes
0
Phospholipids
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Références
J Biol Chem. 2001 Oct 5;276(40):37335-40
pubmed: 11489905
Osteoarthritis Cartilage. 2016 Nov;24(11):1961-1969
pubmed: 27307356
Hum Gene Ther. 2003 Mar 1;14(4):393-402
pubmed: 12659680
Methods Mol Med. 2004;100:129-46
pubmed: 15280593
Tissue Eng. 2002 Apr;8(2):235-45
pubmed: 12031113
Mar Drugs. 2018 Jun 25;16(7):
pubmed: 29941790
Best Pract Res Clin Rheumatol. 2006 Oct;20(5):1003-25
pubmed: 16980220
Colloids Surf B Biointerfaces. 2012 Jun 15;95:75-81
pubmed: 22484065
Mar Drugs. 2020 Apr 13;18(4):
pubmed: 32295082
Histochem Cell Biol. 2001 Jul;116(1):69-77
pubmed: 11479725
Osteoarthritis Cartilage. 2005 Jun;13(6):508-18
pubmed: 15922185
Curr Rheumatol Rep. 2000 Dec;2(6):459-65
pubmed: 11123098
Int J Pharm. 2014 Jan 30;461(1-2):519-28
pubmed: 24355620
Biochim Biophys Acta. 2014 Jun;1838(6):1657-79
pubmed: 24269541
Adv Healthc Mater. 2019 Sep;8(18):e1900506
pubmed: 31402589
Osteoarthritis Cartilage. 2002 Mar;10(3):212-7
pubmed: 11869082
J Biomed Biotechnol. 2010;2010:735349
pubmed: 20625411
Gene Ther. 2000 Feb;7(4):286-91
pubmed: 10694808
Front Biosci. 1999 Oct 15;4:D694-703
pubmed: 10525480
Osteoarthritis Cartilage. 2019 Jun;27(6):932-944
pubmed: 30858101
J Biol Chem. 2000 Apr 21;275(16):12243-50
pubmed: 10766862
J Gene Med. 2003 Jun;5(6):502-9
pubmed: 12797115
J Pharm Sci. 1999 Apr;88(4):454-8
pubmed: 10187757
Curr Drug Deliv. 2007 Jan;4(1):89-101
pubmed: 17269921
Cell Mol Life Sci. 2002 Jan;59(1):5-18
pubmed: 11846033
Biomaterials. 2018 Aug;173:47-57
pubmed: 29758546
Dev Dyn. 1997 Aug;209(4):377-86
pubmed: 9264261
J Clin Invest. 1994 Dec;94(6):2307-16
pubmed: 7989586
Analyst. 2012 Feb 7;137(3):773-86
pubmed: 22158519
Cancer Treat Rev. 2017 Jan;52:48-57
pubmed: 27889637
Sci Rep. 2016 May 27;6:25777
pubmed: 27228907
Food Chem Toxicol. 2008 May;46(5):1771-7
pubmed: 18308443
J Orthop Res. 2018 Jan;36(1):52-63
pubmed: 28763118
Eur Cell Mater. 2018 Oct 12;36:156-170
pubmed: 30311630
Biotechnol Adv. 2018 Nov 15;36(7):1855-1869
pubmed: 30012541
N Engl J Med. 2001 Mar 22;344(12):907-16
pubmed: 11259725
Mar Drugs. 2020 Apr 17;18(4):
pubmed: 32316578
Br J Pharmacol. 2019 May;176(10):1412-1420
pubmed: 29574720
Mater Today Bio. 2020 Feb 27;6:100046
pubmed: 32259100
Methods. 2004 Jun;33(2):151-63
pubmed: 15121170
Clin Orthop Relat Res. 2005 Oct;439:243-52
pubmed: 16205166
J Biomed Mater Res B Appl Biomater. 2003 Aug 15;66(2):559-66
pubmed: 12861608
Molecules. 2019 May 27;24(10):
pubmed: 31137865
Hum Gene Ther. 2001 Jan 20;12(2):117-29
pubmed: 11177549