Unique Gut Microbiome Signatures Depict Diet-Versus Genetically Induced Obesity in Mice.
Type 2 diabetes
diet
leptin
microbiota
obesity
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
13 May 2020
13 May 2020
Historique:
received:
29
03
2020
revised:
25
04
2020
accepted:
09
05
2020
entrez:
17
5
2020
pubmed:
18
5
2020
medline:
13
2
2021
Statut:
epublish
Résumé
The gut microbiome plays an important role in obesity and Type 2 diabetes (T2D); however, it remains unclear whether the gut microbiome could clarify the dietary versus genetic origin of these ailments. Moreover, studies examining the gut microbiome in diet- versus genetically induced obesity/T2D in the same experimental set-up are lacking. We herein characterized the gut microbiomes in three of the most widely used mouse models of obesity/T2D, i.e., genetically induced (leptin-deficient i.e., Lep
Identifiants
pubmed: 32414080
pii: ijms21103434
doi: 10.3390/ijms21103434
pmc: PMC7279357
pii:
doi:
Substances chimiques
Leptin
0
Receptors, Leptin
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : R01AG018915
Pays : United States
Organisme : NIH HHS
ID : UL1TR001420
Pays : United States
Organisme : Congressionally Directed Medical Research Programs
ID : W81XWH-19-1-0236
Organisme : Congressionally Directed Medical Research Programs
ID : W81XWH-18-1-0118
Organisme : NIA NIH HHS
ID : P30 AG021332
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018915
Pays : United States
Organisme : NIH HHS
ID : P30AG21332
Pays : United States
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