Decompensated cirrhosis is the commonest presentation for NAFLD patients undergoing liver transplant assessment.
Non-alcoholic fatty liver disease
cirrhosis
decompensation
prognosis
transplantation
Journal
Clinical medicine (London, England)
ISSN: 1473-4893
Titre abrégé: Clin Med (Lond)
Pays: England
ID NLM: 101092853
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
entrez:
17
5
2020
pubmed:
18
5
2020
medline:
15
5
2021
Statut:
ppublish
Résumé
Non-alcoholic fatty liver disease (NAFLD) accounts for 10-15% of orthotopic liver transplants (OLTs) in the UK. Index presentations with cirrhotic decompensation represent missed opportunities for preventive treatment leaving OLT or palliation as the only options.We retrospectively reviewed patient records for all NAFLD patients undergoing assessment for OLT between January 2003 and December 2017.Data were available for 81 patients with NAFLD as the primary diagnosis. Fifty-two patients had decompensated cirrhosis at first presentation; 91.7% presented to secondary care compared to 52.7% referred from primary care (p=0.001). Cirrhosis was not suspected at the time of referral to hospital in 24.7% of patients subsequently assessed for OLT. Most patients undergoing assessment for OLT for NAFLD had decompensated cirrhosis at their first diagnosis of chronic liver disease. These data highlight the plight of patients with NAFLD cirrhosis in whom chronic liver disease is diagnosed late.
Identifiants
pubmed: 32414722
pii: 20/3/313
doi: 10.7861/clinmed.2019-0250
pmc: PMC7354028
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
313-318Informations de copyright
© Royal College of Physicians 2020. All rights reserved.
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