An Automated Segmentation Pipeline for Intratumoural Regions in Animal Xenografts Using Machine Learning and Saturation Transfer MRI.

Adenocarcinoma / pathology Algorithms Animals Apoptosis Automation Cell Proliferation Female Humans Image Processing, Computer-Assisted / methods Machine Learning Magnetic Resonance Imaging / methods Male Mice Mice, Nude Prostatic Neoplasms / pathology Tumor Cells, Cultured Xenograft Model Antitumor Assays

Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
15 05 2020
Historique:
received: 27 01 2020
accepted: 24 04 2020
entrez: 17 5 2020
pubmed: 18 5 2020
medline: 1 12 2020
Statut: epublish

Résumé

Saturation transfer MRI can be useful in the characterization of different tumour types. It is sensitive to tumour metabolism, microstructure, and microenvironment. This study aimed to use saturation transfer to differentiate between intratumoural regions, demarcate tumour boundaries, and reduce data acquisition times by identifying the imaging scheme with the most impact on segmentation accuracy. Saturation transfer-weighted images were acquired over a wide range of saturation amplitudes and frequency offsets along with T

Identifiants

DOI: 10.1038/s41598-020-64912-6 PMID: 32415137 PMC: PMC7228927
pubmed: 32415137
doi: 10.1038/s41598-020-64912-6
pii: 10.1038/s41598-020-64912-6
pmc: PMC7228927
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

8063

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Auteurs

Wilfred W Lam (WW)

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada. lamw@sri.utoronto.ca.

Wendy Oakden (W)

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

Elham Karami (E)

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON, Canada.

Margaret M Koletar (MM)

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

Leedan Murray (L)

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.

Stanley K Liu (SK)

Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Radiation Oncology, University of Toronto, Toronto, ON, Canada.
Biological Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Ali Sadeghi-Naini (A)

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Electrical Engineering and Computer Science, Lassonde School of Engineering, York University, Toronto, ON, Canada.
Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.

Greg J Stanisz (GJ)

Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada.
Medical Biophysics, University of Toronto, Toronto, ON, Canada.
Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland.

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Classifications MeSH

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