Obesity and Diabetes in an Arab population: Role of Adenovirus 36 Infection.
Adenovirus Infections, Human
/ complications
Adenoviruses, Human
/ isolation & purification
Adiposity
Adult
Arabs
/ statistics & numerical data
Biomarkers
/ analysis
Blood Glucose
/ analysis
Body Weight
Case-Control Studies
Diabetes Mellitus
/ epidemiology
Female
Follow-Up Studies
Glycated Hemoglobin
/ analysis
Humans
Insulin Resistance
Male
Middle Aged
Obesity
/ epidemiology
Prognosis
Risk Factors
United Arab Emirates
/ epidemiology
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
received:
27
03
2019
accepted:
16
04
2020
entrez:
17
5
2020
pubmed:
18
5
2020
medline:
1
12
2020
Statut:
epublish
Résumé
Prior infection with adenovirus 36 (Adv36) has been associated with increased adiposity, improved insulin sensitivity, and a lower prevalence of diabetes. This study investigated the prevalence of Adv36 seropositivity and its association with obesity and diabetes among adults attending a diabetes centre in the UAE.Participants (N = 973) with different weight and glucose tolerance categories were recruited. Adv36 seropositivity (Adv36 + ) was assessed using ELISA. Differences among groups were analyzed using statistical tests as appropriate to the data. Prevalence of Adv36+ in the study population was 47%, with no significant difference in obese and non-obese subgroups (42.5% vs 49.6% respectively; p=non-significant). Females were more likely to be Adv36+ compared to males (odds ratio 1.78; 95% CI 1.36-2.32, p < 0.001). We found no significant association between Adv36 seropositivity and different BMI categories, or glucose tolerance status. In our population, the effect of Adv36 infection on lipid profile varied between healthy individuals and individuals with obesity. Adv36 infection is more prevalent in the UAE than in other countries but has no association with obesity. Our study found that females were more likely to be Adv36 positive regardless of weight or diabetes status.
Identifiants
pubmed: 32415247
doi: 10.1038/s41598-020-65008-x
pii: 10.1038/s41598-020-65008-x
pmc: PMC7229214
doi:
Substances chimiques
Biomarkers
0
Blood Glucose
0
Glycated Hemoglobin A
0
hemoglobin A1c protein, human
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8107Références
Bray, G. A. & Bellanger, T. Epidemiology, trends, and morbidities of obesity and the metabolic syndrome. Endocrine 29, 109–117 (2006).
doi: 10.1385/ENDO:29:1:109
Collaboration, N. R. F. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19· 2 million participants. The Lancet 387, 1377–1396 (2016).
doi: 10.1016/S0140-6736(16)30054-X
Ng, M. et al. Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013. The lancet 384, 766–781 (2014).
doi: 10.1016/S0140-6736(14)60460-8
Abuyassin, B. & Laher, I. Diabetes epidemic sweeping the Arab world. World journal of diabetes 7, 165 (2016).
doi: 10.4239/wjd.v7.i8.165
Atkinson, R. L. in Mayo Clinic Proceedings. 1192-1198 (Elsevier).
Akheruzzaman, M., Hegde, V. & Dhurandhar, N. V. Twenty‐five years of research about adipogenic adenoviruses: A systematic review. Obesity Reviews 20, 499–509 (2019).
doi: 10.1111/obr.12808
Dhurandhar, N. et al. Increased adiposity in animals due to a human virus. International journal of obesity 24, 989 (2000).
doi: 10.1038/sj.ijo.0801319
Vangipuram, S. et al. Adipogenic human adenovirus-36 reduces leptin expression and secretion and increases glucose uptake by fat cells. International journal of obesity 31, 87 (2007).
doi: 10.1038/sj.ijo.0803366
Whigham, L. D., Israel, B. A. & Atkinson, R. L. Adipogenic potential of multiple human adenoviruses in vivo and in vitro in animals. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 290, R190–R194 (2006).
doi: 10.1152/ajpregu.00479.2005
Arnold, J. et al. Genomic characterization of human adenovirus 36, a putative obesity agent. Virus research 149, 152–161 (2010).
doi: 10.1016/j.virusres.2010.01.011
Atkinson, R. L. et al. Human adenovirus-36 is associated with increased body weight and paradoxical reduction of serum lipids. International Journal Of Obesity 29, 281, https://doi.org/10.1038/sj.ijo.0802830 (2004).
doi: 10.1038/sj.ijo.0802830
Broderick, M. et al. Adenovirus 36 seropositivity is strongly associated with race and gender, but not obesity, among US military personnel. International journal of obesity 34, 302 (2010).
J.Goossens, V. et al. Lack of Evidence for the Role of Human Adenovirus‐36 in Obesity in a European Cohort. Obesity 19, 220–221, https://doi.org/10.1038/oby.2009.452 (2011).
doi: 10.1038/oby.2009.452
Bil-Lula, I. et al. Infectobesity in the Polish population-evaluation of an association between adenoviruses type 5, 31, 36 and human obesity. International Journal of Virology and Molecular Biology 3, 1–8 (2014).
Atkinson, R. L., Lee, I., SHIN, H. J. & He, J. Human adenovirus‐36 antibody status is associated with obesity in children. Pediatric Obesity 5, 157–160 (2010).
doi: 10.3109/17477160903111789
Vander Wal, J. S., Huelsing, J., Dubuisson, O. & Dhurandhar, N. V. An observational study of the association between adenovirus 36 antibody status and weight loss among youth. Obesity facts 6, 269–278 (2013).
doi: 10.1159/000353109
Voss, J. D., Burnett, D. G., Olsen, C. H., Haverkos, H. W. & Atkinson, R. L. Adenovirus 36 antibodies associated with clinical diagnosis of overweight/obesity but not BMI gain: a military cohort study. The Journal of Clinical Endocrinology & Metabolism 99, E1708–E1712 (2014).
doi: 10.1210/jc.2014-1863
Berger, P. K. et al. Association of adenovirus 36 infection with adiposity and inflammatory-related markers in children. The Journal of Clinical Endocrinology & Metabolism 99, 3240–3246 (2014).
doi: 10.1210/jc.2014-1780
Parra-Rojas, I. et al. Adenovirus-36 seropositivity and its relation with obesity and metabolic profile in children. International journal of endocrinology 2013 (2013).
Aldhoon-Hainerová, I. et al. Clinical and laboratory characteristics of 1179 Czech adolescents evaluated for antibodies to human adenovirus 36. International Journal Of Obesity 38, 285, https://doi.org/10.1038/ijo.2013.72 (2013).
doi: 10.1038/ijo.2013.72
pubmed: 23732656
Almgren, M. et al. Adenovirus-36 is associated with obesity in children and adults in Sweden as determined by rapid ELISA. Plos one 7, e41652 (2012).
doi: 10.1371/journal.pone.0041652
Trovato, G. M. et al. Human obesity relationship with Ad36 adenovirus and insulin resistance. International Journal Of Obesity 33, 1402, https://doi.org/10.1038/ijo.2009.196 (2009).
doi: 10.1038/ijo.2009.196
pubmed: 19786969
Trovato, G. M. et al. Adenovirus-36 seropositivity enhances effects of nutritional intervention on obesity, bright liver, and insulin resistance. Digestive diseases and sciences 57, 535–544 (2012).
doi: 10.1007/s10620-011-1903-8
Sabin, M. et al. Longitudinal investigation of adenovirus 36 seropositivity and human obesity: the Cardiovascular Risk in Young Finns Study. International journal of obesity 39, 1644 (2015).
doi: 10.1038/ijo.2015.108
Ergin, S. et al. The role of adenovirus 36 as a risk factor in obesity: the first clinical study made in the fatty tissues of adults in Turkey. Microbial pathogenesis 80, 57–62 (2015).
doi: 10.1016/j.micpath.2015.02.008
Karamese, M., Altoparlak, U., Turgut, A., Aydogdu, S. & Karamese, S. A. The relationship between adenovirus-36 seropositivity, obesity and metabolic profile in Turkish children and adults. Epidemiology & Infection 143, 3550–3556 (2015).
doi: 10.1017/S0950268815000679
Na, H. et al. Association of human adenovirus-36 in overweight Korean adults. International Journal of Obesity 36, 281 (2012).
doi: 10.1038/ijo.2011.102
Lin, W.-Y. et al. Long-Term Changes in Adiposity and Glycemic Control Are Associated With Past Adenovirus Infection. Diabetes Care 36, 701–707, https://doi.org/10.2337/dc12-1089 (2013).
doi: 10.2337/dc12-1089
pubmed: 23160725
pmcid: 3579356
Sapunar, J. et al. Adenovirus 36 seropositivity is related to obesity risk, glycemic control, and leptin levels in Chilean subjects. International Journal of Obesity, 1 (2019).
Pasarica, M. et al. Human adenovirus 36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines in rats. Obesity 14, 1905–1913 (2006).
doi: 10.1038/oby.2006.222
Dhurandhar, N. V., Dhurandhar, E. J., Ingram, D. K., Vaughan, K. & Mattison, J. A. Natural infection of human adenovirus 36 in rhesus monkeys is associated with a reduction in fasting glucose. Journal of diabetes 6, 614–616 (2014).
doi: 10.1111/1753-0407.12178
Almgren, M. et al. Human adenovirus-36 is uncommon in type 2 diabetes and is associated with increased insulin sensitivity in adults in Sweden. Annals of medicine 46, 539–546 (2014).
doi: 10.3109/07853890.2014.935469
Waye, M., Chan, J., Tong, P., Ma, R. & Chan, P. Association of human adenovirus-36 with diabetes, adiposity, and dyslipidaemia in Hong Kong Chinese. Hong Kong Med J 21 (2015).
IDF. IDF Diabetes Atlas, 8th Edition, 2017, Country reports -United Arab Emirates, http://reports.instantatlas.com/report/view/846e76122b5f476fa6ef09471965aedd/ARE (2017).
Dhurandhar, N. V. et al. Human adenovirus Ad-36 promotes weight gain in male rhesus and marmoset monkeys. The Journal of Nutrition 132, 3155–3160 (2002).
doi: 10.1093/jn/131.10.3155
Qinglong, S. et al. Serological data analyses show that adenovirus 36 infection is associated with obesity: A meta‐analysis involving 5739 subjects. Obesity 22, 895–900, https://doi.org/10.1002/oby.20533 (2014).
doi: 10.1002/oby.20533
Yamada, T., Hara, K. & Kadowaki, T. Association of Adenovirus 36 Infection with Obesity and Metabolic Markers in Humans: A Meta-Analysis of Observational. Studies. PLoS ONE 7, e42031, https://doi.org/10.1371/journal.pone.0042031 (2012).
doi: 10.1371/journal.pone.0042031
pubmed: 22848697
Ehsandar, S. et al. Prevalence of Human Adenovirus 36 and Its Association with Overweight/Obese and Lipid Profiles in the Tehran Lipid and Glucose Study. Iranian Journal of Endocrinology and Metabolism 16, 88–94 (2014).
Zhou, Y. et al. The relationship between human adenovirus 36 and obesity in Chinese Han population. Bioscience reports, BSR20180553 (2018).
Wang, Z. Q. et al. Human Adenovirus Type 36 Enhances Glucose Uptake in Diabetic and Nondiabetic Human Skeletal Muscle Cells Independent of Insulin Signaling. Diabetes 57, 1805–1813, https://doi.org/10.2337/db07-1313 (2008).
doi: 10.2337/db07-1313
pubmed: 18420488
pmcid: 2453622
Krishnapuram, R. et al. Insulin receptor-independent upregulation of cellular glucose uptake. International Journal of Obesity 37, 146 (2013).
doi: 10.1038/ijo.2012.6
McMurphy, T. B. et al. Hepatic Expression of Adenovirus 36 E4ORF1 Improves Glycemic Control and Promotes Glucose Metabolism via AKT Activation. Diabetes, db160876 (2016).
Mäkelä, M. et al. Enteral virus infections in early childhood and an enhanced type 1 diabetes-associated antibody response to dietary insulin. Journal of autoimmunity 27, 54–61 (2006).
doi: 10.1016/j.jaut.2006.04.003
Dubuisson, O., Day, R. S. & Dhurandhar, N. V. Accurate identification of neutralizing antibodies to adenovirus Ad36,-a putative contributor of obesity in humans. Journal of Diabetes and its Complications 29, 83–87 (2015).
doi: 10.1016/j.jdiacomp.2014.09.004
Nam, J., Na, H., Atkinson, R. & Dhurandhar, N. Genomic stability of adipogenic human adenovirus 36. International Journal of Obesity 38, 321 (2014).
doi: 10.1038/ijo.2013.67
Sang, Y. et al. Ileal transcriptome analysis in obese rats induced by high-fat diets and an adenoviral infection. International Journal of Obesity, 1 (2019).
Glass, G. V. Testing Homogeneity of Variances. American Educational Research Journal 3, 187–190, https://doi.org/10.3102/00028312003003187 (1966).
doi: 10.3102/00028312003003187