Lymphopenia and lymphocytosis in practical healthy people born and living in the North.
G-CSF
NFATc1
lymphocytosis
lymphopenia
neutropenia
Journal
Immunity, inflammation and disease
ISSN: 2050-4527
Titre abrégé: Immun Inflamm Dis
Pays: England
ID NLM: 101635460
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
14
04
2020
accepted:
30
04
2020
pubmed:
18
5
2020
medline:
22
9
2021
entrez:
17
5
2020
Statut:
ppublish
Résumé
The purpose of this study was to elucidate the mechanisms of the formation of lymphopenia and lymphocytosis in healthy people, who are living and working in the Arctic region. A total of 88 practically healthy people living and working in the Arctic region were examined. An analysis of the results was carried out, depending on the concentration of lymphocytes in the peripheral venous blood: group 1-with lymphopenia, the content of lymphocytes below 1.5 × 10 It has been established that the main mechanism for the formation of lymphopenia in a person living in the Arctic is the activation of the migration of functionally active lymphocytes in the tissue. The decrease in the number of circulating lymphocytes is a consequence of their redistribution from the circulating pool to the marginal one and an increase in the activity of adhesive molecules, in particular, the selectin ligand. It was revealed that an increase in the content of lymphocytes in the blood occurs upon the activation of the intracellular energy-intensive mechanisms of lymphoproliferation with an increase in the consumption of intracellular ATP and the participation of the nuclear factor of activated T cells 1. It was shown that the restoration of the circulating pool of mature neutrophils is ensured by the principle of reverse regulation in response to neutropenia by stimulating granulocyte-colony stimulating factor granulopoiesis. The main mechanism for the formation of lymphopenia and lymphocytosis in healthy people was established.
Identifiants
pubmed: 32415758
doi: 10.1002/iid3.308
pmc: PMC7416049
doi:
Substances chimiques
Granulocyte Colony-Stimulating Factor
143011-72-7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
320-324Informations de copyright
© 2020 The Authors. Immunity, Inflammation and Disease published by John Wiley & Sons Ltd.
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