Compound muscle action potential scan and MScanFit motor unit number estimation during Wallerian degeneration after nerve transections.
Action Potentials
/ physiology
Adolescent
Adult
Disease Progression
Electrodiagnosis
Electromyography
Female
Humans
Male
Median Nerve
/ injuries
Middle Aged
Motor Neurons
/ physiology
Neural Conduction
/ physiology
Peripheral Nerve Injuries
/ physiopathology
Ulnar Nerve
/ injuries
Wallerian Degeneration
/ physiopathology
Young Adult
CMAP scan
MScanFit
MUNE
Wallerian degeneration
peripheral nerve injury
stimulus response curve
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
18
01
2020
revised:
10
05
2020
accepted:
11
05
2020
pubmed:
18
5
2020
medline:
26
9
2020
entrez:
17
5
2020
Statut:
ppublish
Résumé
Compound muscle action potential (CMAP) scan and MScanFit have been used to understand the consequences of denervation and reinnervation. This study aimed to monitor these parameters during Wallerian degeneration (WD) after acute nerve transections (ANT). Beginning after urgent surgery, CMAP scans were recorded at 1-2 day intervals in 12 patients with ANT of the ulnar or median nerves, by stimulating the distal stump (DS). Stimulus intensities (SI), steps, returners, and MScanFit were calculated. Studies were grouped according to the examination time after ANT. Results were compared with those of 27 controls. CMAP amplitudes and MScanFit progressively declined, revealing a positive correlation with one another. SIs were higher in WD groups than controls. Steps appeared or disappeared in follow-up scans. The late WD group had higher returner% than the early WD and control groups. MScanFit can monitor neuromuscular dysfunction during WD. SIs revealed excitability changes in DS.
Sections du résumé
BACKGROUND
Compound muscle action potential (CMAP) scan and MScanFit have been used to understand the consequences of denervation and reinnervation. This study aimed to monitor these parameters during Wallerian degeneration (WD) after acute nerve transections (ANT).
METHODS
Beginning after urgent surgery, CMAP scans were recorded at 1-2 day intervals in 12 patients with ANT of the ulnar or median nerves, by stimulating the distal stump (DS). Stimulus intensities (SI), steps, returners, and MScanFit were calculated. Studies were grouped according to the examination time after ANT. Results were compared with those of 27 controls.
RESULTS
CMAP amplitudes and MScanFit progressively declined, revealing a positive correlation with one another. SIs were higher in WD groups than controls. Steps appeared or disappeared in follow-up scans. The late WD group had higher returner% than the early WD and control groups.
CONCLUSIONS
MScanFit can monitor neuromuscular dysfunction during WD. SIs revealed excitability changes in DS.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
239-246Informations de copyright
© 2020 Wiley Periodicals, Inc.
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