Home-based HPV self-sampling assisted by a cloud-based electronic data system: Lessons learnt from a pilot community cervical cancer screening campaign in rural Ethiopia.
Adult
Aged
Cloud Computing
Early Detection of Cancer
/ methods
Electronic Data Processing
/ methods
Ethiopia
Female
Health Promotion
/ methods
Humans
Middle Aged
Papillomavirus Infections
/ diagnosis
Pilot Projects
Rural Population
Self-Testing
Specimen Handling
/ methods
Uterine Cervical Neoplasms
/ diagnosis
Uterine Cervical Dysplasia
/ diagnosis
Cervical cancer screening
Community
Electronic data system
Ethiopia
HPV testing
Home-based
Rural
Self-sampling
eHealth
p16/ki-67 dual stain cytology
Journal
Papillomavirus research (Amsterdam, Netherlands)
ISSN: 2405-8521
Titre abrégé: Papillomavirus Res
Pays: Netherlands
ID NLM: 101662552
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
16
12
2019
revised:
23
04
2020
accepted:
27
04
2020
pubmed:
18
5
2020
medline:
7
4
2021
entrez:
17
5
2020
Statut:
ppublish
Résumé
Primary HPV testing and triage of HPV-positive women is an effective cervical cancer screening strategy. Such a multi-visit screening algorithm is also promising for community-based screening in resource-poor communities, provided a robust tracking system is in place. A cervical cancer screening campaign was conducted in a rural community in Ethiopia. All women aged 25-65 years were offered genital self-sampling using the Evalyn Brush®. Samples were HPV-DNA-tested at a central laboratory. Key indicators were captured on tablet computers and linked by a cloud-based information system. HPV-positive women were examined at the local clinic using portable colposcopy, p16/Ki-67 dual stain cytology and biopsy examination. CIN2+ women were referred for LEEP to the referral hospital. Of 749 enumerated age-eligible women 634 (85%, (95% CI 82-88)) consented to screening, 429 samples were adequate for HPV testing, giving a total testing coverage of 57% (95% CI 53-62). The hrHPV prevalence was 14% (95% CI 5-22), 72% (95% CI 60-84) attended the clinic for a triage examination. Home-based HPV-DNA self-sampling and clinic-based triage assisted by cloud-based information technology is feasible in rural Ethiopia. Key components of such strategy are broad community awareness, high competency of community workers, and establishment of an adequate self-sampling and HPV-DNA testing platform.
Identifiants
pubmed: 32416283
pii: S2405-8521(20)30005-7
doi: 10.1016/j.pvr.2020.100198
pmc: PMC7240728
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
100198Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Références
BMJ. 2018 Dec 5;363:k4823
pubmed: 30518635
Trop Med Int Health. 2009 Oct;14(10):1287-302
pubmed: 19772550
BMC Womens Health. 2018 Jun 11;18(1):89
pubmed: 29890991
PLoS Med. 2008 Jun 17;5(6):e132
pubmed: 18563963
Papillomavirus Res. 2018 Jun;5:192-200
pubmed: 29689311
N Engl J Med. 2013 Jun 6;368(23):2149-52
pubmed: 23738542
Glob Health Sci Pract. 2016 Mar 25;4(1):87-98
pubmed: 27016546
Reprod Health. 2018 Dec 12;15(1):206
pubmed: 30541595
J Glob Oncol. 2016 Oct 12;3(5):635-657
pubmed: 29094101
Rev Obstet Gynecol. 2009 Fall;2(4):240-4
pubmed: 20111660
BMC Womens Health. 2018 Jul 3;18(1):116
pubmed: 29970063
Int J Gynaecol Obstet. 2018 Apr;141(1):63-69
pubmed: 29197067
Lancet Glob Health. 2015 Feb;3(2):e85-94
pubmed: 25617202
Int J Gynecol Cancer. 2014 Feb;24(2):339-45
pubmed: 24326529
Gynecol Oncol. 2017 Jan;144(1):51-56
pubmed: 28094038
Int J Gynaecol Obstet. 2013 Aug;122(2):118-23
pubmed: 23731506
J Clin Microbiol. 2008 Mar;46(3):1050-9
pubmed: 18199790
Cancer Causes Control. 2016 Oct;27(10):1253-9
pubmed: 27581249
Int J Gynecol Cancer. 2013 Mar;23(3):507-12
pubmed: 23354369
BMC Public Health. 2019 Jan 3;19(1):14
pubmed: 30606132
J Med Virol. 2020 Jan;92(1):113-118
pubmed: 31471920
J Glob Oncol. 2018 Sep;4:1-5
pubmed: 30241142
Trop Med Int Health. 2015 Oct;20(10):1355-67
pubmed: 26031572
Eur J Cancer. 2015 Nov;51(16):2375-85
pubmed: 26296294
Cancer Prev Res (Phila). 2019 Sep;12(9):609-616
pubmed: 31337647
BMC Cancer. 2013 Jan 02;13:2
pubmed: 23282173
JAMA Intern Med. 2019 Jul 1;179(7):881-888
pubmed: 31081870
Intervirology. 2019;62(3-4):124-133
pubmed: 31487743
BMJ Open. 2018 Jun 12;8(6):e020484
pubmed: 29895648
PLoS One. 2016 Jun 16;11(6):e0157217
pubmed: 27310005
Afr Health Sci. 2018 Sep;18(3):623-636
pubmed: 30602995
Prev Med. 2017 Aug;101:96-101
pubmed: 28579497
Int J Gynaecol Obstet. 2014 Jan;124(1):12-8
pubmed: 24140218
Virol J. 2019 Jul 23;16(1):92
pubmed: 31337408
Vaccine. 2013 Dec 29;31 Suppl 5:F53-9
pubmed: 24331748
Clinics (Sao Paulo). 2017 Mar;72(3):183-187
pubmed: 28355365
Sex Transm Dis. 2015 Nov;42(11):607-11
pubmed: 26462184
J Clin Virol. 2016 Mar;76 Suppl 1:S14-S21
pubmed: 26522865
Nature. 2015 Dec 3;528(7580):S77-85
pubmed: 26633769
Lancet. 2011 Nov 26;378(9806):1868-73
pubmed: 22051739
Cancer Epidemiol Biomarkers Prev. 2012 Sep;21(9):1434-8
pubmed: 22806169
J Community Health. 2014 Jun;39(3):409-15
pubmed: 24276617
Int J Cancer. 2020 Jul 1;147(1):128-138
pubmed: 31633801
BMC Public Health. 2019 May 29;19(Suppl 1):603
pubmed: 31138174
Int J Womens Health. 2015 Jul 31;7:765-72
pubmed: 26261427
Int J Gynaecol Obstet. 2016 Mar;132(3):259-65
pubmed: 26851054
Lancet Oncol. 2014 Feb;15(2):172-83
pubmed: 24433684
Glob Health Action. 2019;12(1):1587894
pubmed: 30938248
J Natl Cancer Inst. 2019 Sep 1;111(9):923-932
pubmed: 30629194
Int J Cancer. 2013 Dec 1;133(11):2681-7
pubmed: 23712523
Int J Gynecol Cancer. 2019 Jan;29(1):23-27
pubmed: 30640679
Int J Gynaecol Obstet. 2015 Mar;128(3):206-10
pubmed: 25468050
Int J Gynaecol Obstet. 2017 Jul;138 Suppl 1:33-40
pubmed: 28691330
BMJ Open. 2017 Oct 22;7(10):e015496
pubmed: 29061601
Glob Health Sci Pract. 2018 Jun 29;6(2):242-246
pubmed: 29959268
Pan Afr Med J. 2014 Mar 11;17:189
pubmed: 25396015
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
BMJ Glob Health. 2019 May 14;4(3):e001351
pubmed: 31179035
Asian Pac J Cancer Prev. 2014;15(20):8563-9
pubmed: 25374168
Gynecol Oncol. 2018 Jan;148(1):118-125
pubmed: 29153541
J Natl Cancer Inst. 2012 Feb 8;104(3):178-88
pubmed: 22271765