A core outcome set for pre-eclampsia research: an international consensus development study.
Consensus development study
core outcome set
modified Delphi method
modified nominal group technique
outcome reporting bias
pre-eclampsia
Journal
BJOG : an international journal of obstetrics and gynaecology
ISSN: 1471-0528
Titre abrégé: BJOG
Pays: England
ID NLM: 100935741
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
accepted:
11
05
2020
pubmed:
18
5
2020
medline:
30
10
2020
entrez:
17
5
2020
Statut:
ppublish
Résumé
To develop a core outcome set for pre-eclampsia. Consensus development study. International. Two hundred and eight-one healthcare professionals, 41 researchers and 110 patients, representing 56 countries, participated. Modified Delphi method and Modified Nominal Group Technique. A long-list of 116 potential core outcomes was developed by combining the outcomes reported in 79 pre-eclampsia trials with those derived from thematic analysis of 30 in-depth interviews of women with lived experience of pre-eclampsia. Forty-seven consensus outcomes were identified from the Delphi process following which 14 maternal and eight offspring core outcomes were agreed at the consensus development meeting. Maternal core outcomes: death, eclampsia, stroke, cortical blindness, retinal detachment, pulmonary oedema, acute kidney injury, liver haematoma or rupture, abruption, postpartum haemorrhage, raised liver enzymes, low platelets, admission to intensive care required, and intubation and ventilation. Offspring core outcomes: stillbirth, gestational age at delivery, birthweight, small-for-gestational-age, neonatal mortality, seizures, admission to neonatal unit required and respiratory support. The core outcome set for pre-eclampsia should underpin future randomised trials and systematic reviews. Such implementation should ensure that future research holds the necessary reach and relevance to inform clinical practice, enhance women's care and improve the outcomes of pregnant women and their babies. 281 healthcare professionals, 41 researchers and 110 women have developed #preeclampsia core outcomes @HOPEoutcomes @jamesmnduffy. [Correction added on 29 June 2020, after first online publication: the order has been corrected.].
Identifiants
pubmed: 32416644
doi: 10.1111/1471-0528.16319
doi:
Types de publication
Consensus Development Conference
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1516-1526Subventions
Organisme : Department of Health
ID : NIHR-RP-02-12-015
Pays : United Kingdom
Organisme : Barts Charity
Pays : International
Organisme : Department of Health
ID : RP-PG-0614-20005
Pays : United Kingdom
Organisme : Elisabeth Garrett Anderson Hospital Charity Travelling Fellowship in Memory of Anne Boutwood
Pays : International
Organisme : British Heart Foundation
ID : FS/15/32/31604
Pays : United Kingdom
Organisme : Department of Health
ID : DRF-2014-07-051
Pays : United Kingdom
Organisme : Department of Health
ID : RP-2014-05-019
Pays : United Kingdom
Organisme : National Institute for Health Research
Pays : International
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors. BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd on behalf of Royal College of Obstetricians and Gynaecologists.
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