Combination of Naringenin and Lisinopril Ameliorates Nephropathy in Type-1 Diabetic Rats.
Animals
Blood Glucose
/ metabolism
Diabetes Mellitus, Experimental
/ chemically induced
Diabetes Mellitus, Type 1
/ chemically induced
Diabetic Nephropathies
/ etiology
Drug Therapy, Combination
Flavanones
/ administration & dosage
Kidney
/ drug effects
Lisinopril
/ administration & dosage
Male
Oxidative Stress
/ drug effects
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species
/ metabolism
Streptozocin
Diabetic nephropathy
Type-1 diabetes
diabetic complications
flavonoids
lisinopril
naringenin
Journal
Endocrine, metabolic & immune disorders drug targets
ISSN: 2212-3873
Titre abrégé: Endocr Metab Immune Disord Drug Targets
Pays: United Arab Emirates
ID NLM: 101269157
Informations de publication
Date de publication:
2021
2021
Historique:
received:
28
11
2019
revised:
05
03
2020
accepted:
21
04
2020
pubmed:
18
5
2020
medline:
3
11
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
Diabetes is a metabolic disorder affecting a large percentage of the population worldwide. The chronic hyperglycemic condition leads to the generation of advanced glycation end products, reactive oxygen species and inflammatory cytokines, which worsen the functioning of the kidney. Clinical management of diabetic nephropathy is difficult as it requires a multi-focused approach. Hence, a combination of lisinopril a drug used in clinical practice for nephropathy, and naringenin, a flavonoid reported to have a significant effect in nephropathy, may show additive or synergistic effect with less side effects. The objective of the present study was to evaluate the effect of a combination of lisinopril with naringenin in diabetic nephropathy. Diabetes was induced in male Sprague Dawley rats by streptozotocin (55 mg/kg, i.p.). After four weeks of diabetes induction animals were treated with naringenin alone and a combination of Lisinopril and naringenin for the next four weeks. At the end of the study, various urine and biochemical parameters were evaluated. Oxidative stress parameters like malondialdehyde, reduced glutathione; catalase and superoxide dismutase for kidney tissues were estimated and histopathology studies of kidneys were carried out. The combination of lisinopril (10 mg/kg) and naringenin (25 and 50 mg/kg) treatment showed significant improvement in the biochemical and urine parameters. Combination treatment also attenuated renal oxidative stress and renal damage as observed in histopathological studies. Treatment with a combination of lisinopril and naringenin showed a promising effect on diabetic nephropathy in rats.
Sections du résumé
BACKGROUND
BACKGROUND
Diabetes is a metabolic disorder affecting a large percentage of the population worldwide. The chronic hyperglycemic condition leads to the generation of advanced glycation end products, reactive oxygen species and inflammatory cytokines, which worsen the functioning of the kidney. Clinical management of diabetic nephropathy is difficult as it requires a multi-focused approach. Hence, a combination of lisinopril a drug used in clinical practice for nephropathy, and naringenin, a flavonoid reported to have a significant effect in nephropathy, may show additive or synergistic effect with less side effects.
OBJECTIVE
OBJECTIVE
The objective of the present study was to evaluate the effect of a combination of lisinopril with naringenin in diabetic nephropathy.
METHODS
METHODS
Diabetes was induced in male Sprague Dawley rats by streptozotocin (55 mg/kg, i.p.). After four weeks of diabetes induction animals were treated with naringenin alone and a combination of Lisinopril and naringenin for the next four weeks. At the end of the study, various urine and biochemical parameters were evaluated. Oxidative stress parameters like malondialdehyde, reduced glutathione; catalase and superoxide dismutase for kidney tissues were estimated and histopathology studies of kidneys were carried out.
RESULTS
RESULTS
The combination of lisinopril (10 mg/kg) and naringenin (25 and 50 mg/kg) treatment showed significant improvement in the biochemical and urine parameters. Combination treatment also attenuated renal oxidative stress and renal damage as observed in histopathological studies.
CONCLUSION
CONCLUSIONS
Treatment with a combination of lisinopril and naringenin showed a promising effect on diabetic nephropathy in rats.
Identifiants
pubmed: 32416710
pii: EMIDDT-EPUB-106679
doi: 10.2174/1871530320666200516163919
doi:
Substances chimiques
Blood Glucose
0
Flavanones
0
Reactive Oxygen Species
0
Streptozocin
5W494URQ81
Lisinopril
E7199S1YWR
naringenin
HN5425SBF2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-182Informations de copyright
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