Decellularized Extracellular Matrix for Bioengineering Physiomimetic 3D in Vitro Tumor Models.
decellularization
extracellular matrix
physiomimetic 3D tumor models
preclinical in vitro screening
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
13
03
2020
revised:
10
04
2020
accepted:
14
04
2020
pubmed:
18
5
2020
medline:
24
9
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
Recent advances in the extraction and purification of decellularized extracellular matrix (dECM) obtained from healthy or malignant tissues open new avenues for engineering physiomimetic 3D in vitro tumor models, which closely recapitulate key biomolecular hallmarks and the dynamic cancer cell-ECM interactions in the tumor microenvironment. We review current and upcoming methodologies for chemical modification of dECM-based biomaterials and advanced bioprocessing into organotypic 3D solid tumor models. A comprehensive review of disruptive advances and shortcomings of exploring dECM-based biomaterials for recapitulating the native tumor-supporting matrix is also provided. We hope to drive the discussion on how 3D dECM testing platforms can be leveraged for generating microphysiological tumor surrogates that generate more robust and predictive data on therapeutic bioperformance.
Identifiants
pubmed: 32416940
pii: S0167-7799(20)30111-6
doi: 10.1016/j.tibtech.2020.04.006
pii:
doi:
Substances chimiques
Biocompatible Materials
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1397-1414Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.