Role of cyclins and cyclin-dependent kinases in pluripotent stem cells and their potential as a therapeutic target.
CDK inhibitor
Cyclin
Cyclin-dependent kinases
Pluripotent stem cells
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
20
03
2020
revised:
30
04
2020
accepted:
02
05
2020
pubmed:
18
5
2020
medline:
11
8
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
Over the last 15 years connections between cell cycle control, maintenance of pluripotency, and control of cell fate decisions have been firmly established. With the emergence of powerful tools, such as highly-specific small molecule inhibitors for cyclin-dependent protein kinase (CDK) activity and single-cell imaging technologies, the mechanistic links between cyclins, CDKs and regulation in PSCs in mechanistic detail has been made possible. In this review, we discuss new developments that mechanistically link the CDK regulatory network to control of cell fate decisions, including maintenance of the pluripotent state. Overall, these findings have potential to impact the translational applications of stem cells in regenerative medicine, drug discovery and cancer treatment.
Identifiants
pubmed: 32417217
pii: S1084-9521(20)30044-6
doi: 10.1016/j.semcdb.2020.05.001
pmc: PMC7554155
mid: NIHMS1594363
pii:
doi:
Substances chimiques
Cyclins
0
Cyclin-Dependent Kinases
EC 2.7.11.22
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
63-71Subventions
Organisme : NIGMS NIH HHS
ID : P01 GM085354
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL089471
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
Références
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Cell Death Differ. 2017 Jan;24(1):38-48
pubmed: 27636107
Oncogene. 1994 Mar;9(3):809-18
pubmed: 8108123
Cell Cycle. 2010 May 15;9(10):1986-9
pubmed: 20473026
Oncologist. 2015 Apr;20(4):366-7
pubmed: 25777347
Dev Dyn. 1996 May;206(1):1-11
pubmed: 9019240
Development. 2017 Oct 15;144(20):3633-3645
pubmed: 29042475
PLoS Genet. 2014 Mar 06;10(3):e1004204
pubmed: 24603501
Nature. 2007 Aug 16;448(7155):811-5
pubmed: 17700700
J Cancer. 2015 Aug 22;6(10):1011-9
pubmed: 26366215
Breast Cancer. 2020 May;27(3):415-425
pubmed: 31823286
Front Cell Dev Biol. 2018 Jun 19;6:57
pubmed: 29974052
Development. 2016 Jan 1;143(1):24-34
pubmed: 26586221
Genes Dev. 2016 Nov 15;30(22):2538-2550
pubmed: 27920086
Genes Dev. 2013 Feb 1;27(3):251-60
pubmed: 23355396
Nucleic Acids Res. 2018 Jul 27;46(13):6544-6560
pubmed: 29901724
Nature. 2008 Dec 4;456(7222):593-8
pubmed: 19052619
Adv Enzyme Regul. 2010;50(1):375-99
pubmed: 20045433
Mol Cell Proteomics. 2016 Jul;15(7):2448-61
pubmed: 27134283
Nat Cell Biol. 2017 Mar;19(3):177-188
pubmed: 28192421
Cell Discov. 2017 Apr 18;3:17010
pubmed: 28480051
Stem Cells. 2016 Jun;34(6):1427-36
pubmed: 26889666
Science. 1992 Sep 18;257(5077):1689-94
pubmed: 1388288
Biochem Biophys Res Commun. 2013 Jan 25;430(4):1329-33
pubmed: 23261434
Nat Rev Cancer. 2018 Nov;18(11):669-680
pubmed: 30228301
Biochem J. 2013 Apr 15;451(2):135-43
pubmed: 23535166
Hepatology. 2019 Nov;70(5):1614-1630
pubmed: 31077409
Cell Stem Cell. 2009 Jun 5;4(6):487-92
pubmed: 19497275
Cancer Res. 2018 Dec 1;78(23):6561-6574
pubmed: 30297536
PLoS One. 2019 Oct 10;14(10):e0223555
pubmed: 31600301
Cell Rep. 2017 May 16;19(7):1283-1293
pubmed: 28514649
Nat Cell Biol. 2019 Sep;21(9):1060-1067
pubmed: 31481793
Nat Commun. 2019 Jun 3;10(1):2400
pubmed: 31160565
Nat Cell Biol. 2016 Nov;18(11):1139-1148
pubmed: 27723719
Nat Rev Mol Cell Biol. 2016 May;17(5):280-92
pubmed: 27033256
Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4344-9
pubmed: 9539739
Elife. 2014 Jun 04;3:
pubmed: 24876129
Cell Death Dis. 2019 Mar 20;10(4):271
pubmed: 30894510
Trends Cell Biol. 2015 Oct;25(10):592-600
pubmed: 26410405
Curr Biol. 2011 Jan 11;21(1):45-52
pubmed: 21167714
Cell. 2013 Sep 26;155(1):13-4
pubmed: 24074854
Nature. 2008 May 22;453(7194):519-23
pubmed: 18497825
Oncogene. 2009 Jan 8;28(1):20-30
pubmed: 18806832
Cell Stem Cell. 2016 Mar 3;18(3):323-329
pubmed: 26853856
Br J Cancer. 2014 Sep 9;111(6):1054-9
pubmed: 24853181
Cell Stem Cell. 2008 Apr 10;2(4):333-44
pubmed: 18397753
Science. 1996 Dec 6;274(5293):1646-52
pubmed: 8939845
Cell Cycle. 2012 Jan 1;11(1):57-64
pubmed: 22186781
Sci Rep. 2016 Oct 19;6:35383
pubmed: 27759034
Cell. 2014 Mar 13;156(6):1338
pubmed: 28898638
J Biol Chem. 2015 Sep 11;290(37):22782-94
pubmed: 26139602
Cell. 2014 Sep 11;158(6):1254-1269
pubmed: 25215486
Mol Cell Biol. 2000 May;20(10):3497-509
pubmed: 10779339
Nat Rev Cancer. 2017 Jan 27;17(2):93-115
pubmed: 28127048
Development. 2011 Oct;138(19):4267-77
pubmed: 21852393
Cell. 2006 Mar 24;124(6):1111-5
pubmed: 16564000
Cell Mol Life Sci. 2007 Dec;64(23):3084-104
pubmed: 17891333
Oncogene. 2002 Nov 28;21(54):8320-33
pubmed: 12447695
Genes Dev. 2016 Feb 15;30(4):421-33
pubmed: 26883361
Cell. 2001 Jun 1;105(5):645-55
pubmed: 11389834
J Biol Chem. 2005 Apr 1;280(13):12976-87
pubmed: 15659392
Oncogene. 1994 Dec;9(12):3635-45
pubmed: 7526316
Oncotarget. 2015 Jun 30;6(18):15788-801
pubmed: 26158861
Mol Biol Cell. 2005 Apr;16(4):2018-27
pubmed: 15703208
Cell Cycle. 2019 Oct;18(20):2697-2712
pubmed: 31462142
Cancer Res. 2018 May 15;78(10):2638-2653
pubmed: 29437706
FEBS J. 2006 Apr;273(8):1723-30
pubmed: 16623708
Nature. 1989 May 25;339(6222):275-80
pubmed: 2566917
Cell Stem Cell. 2014 Oct 2;15(4):471-487
pubmed: 25090446
Nat Rev Mol Cell Biol. 2008 Jul;9(7):505-16
pubmed: 18568039
Stem Cell Reports. 2015 Sep 8;5(3):323-36
pubmed: 26278042
Stem Cell Res. 2013 Jan;10(1):118-31
pubmed: 23178806
J Biol Chem. 2019 Nov 22;294(47):17903-17914
pubmed: 31515269
Nat Cell Biol. 2002 May;4(5):358-66
pubmed: 11988738
Cell Death Dis. 2014 Nov 06;5:e1508
pubmed: 25375373
Front Oncol. 2018 Dec 12;8:608
pubmed: 30631751
Cell. 2007 Nov 30;131(5):861-72
pubmed: 18035408
Cell. 2012 Aug 17;150(4):725-37
pubmed: 22901805
Nat Cell Biol. 2002 Jul;4(7):523-8
pubmed: 12080347
Genes Dev. 2001 Dec 15;15(24):3278-85
pubmed: 11751633
Nat Commun. 2013;4:1464
pubmed: 23403565
Sci Rep. 2019 Sep 10;9(1):13014
pubmed: 31506466
Science. 2010 Jan 29;327(5965):542-5
pubmed: 20110496
Mol Cancer Ther. 2015 Aug;14(8):1848-57
pubmed: 26037781
Genome Res. 2019 Feb;29(2):250-260
pubmed: 30655337
Cell Cycle. 2014;13(9):1384-91
pubmed: 24675894
Stem Cells Int. 2019 May 2;2019:5171032
pubmed: 31191673
Sci Transl Med. 2017 Apr 26;9(387):
pubmed: 28446688
Oncogene. 1996 Mar 21;12(6):1173-80
pubmed: 8649818
PLoS One. 2014 Jul 28;9(7):e102535
pubmed: 25068516
Elife. 2016 Nov 19;5:
pubmed: 27855781
Cell Stem Cell. 2017 Oct 5;21(4):449-455.e4
pubmed: 28985526