A direct look at the dysfunction and pathology of the β cells in human type 2 diabetes.
Beta cell mass
Beta cells
De-differentiation
Inflammation
Insulin secretion
Pancreatic islets
Type 2 diabetes
Journal
Seminars in cell & developmental biology
ISSN: 1096-3634
Titre abrégé: Semin Cell Dev Biol
Pays: England
ID NLM: 9607332
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
24
01
2020
revised:
27
03
2020
accepted:
09
04
2020
pubmed:
18
5
2020
medline:
25
6
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
β cells uniquely produce and secrete insulin under the control of several, integrated signals, to maintain blood glucose concentrations within a narrow physiological interval. β cell failure is key to the onset and progression of type 2 diabetes, due to impaired function and reduced mass. In this review we focus on several features of human β cell dysfunction and pathology in type 2 diabetes, as revealed by direct assessment of isolated islet traits and examination of pancreatic tissue from organ donors, surgical samples or autoptic specimens. Insulin secretion defects and pathology findings are discussed in relation to some of the major underlying mechanisms, to also provide clues for conceiving better prevention and treatment of type 2 diabetes by targeting the pancreatic β cells.
Identifiants
pubmed: 32417220
pii: S1084-9521(19)30053-9
doi: 10.1016/j.semcdb.2020.04.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-93Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.