Mitochondrial biogenesis: a potential therapeutic target for osteoarthritis.
Mfn2
Mitochondrial dynamics
Osteoarthritis
Journal
Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
26
03
2020
accepted:
30
03
2020
pubmed:
18
5
2020
medline:
28
7
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
Mitochondrial dysfunction of human articular chondrocytes is considered a hallmark of cartilage degradation and OA pathogenesis. Due to the huge number of cellular processes in which mitochondria is implicated, even in the closed context of cellular respiration, the term mitochondrial function can refer to a variety of features which include fusion and fission, turnover (biogenesis and mitophagy), and plasticity. Mitochondrial biogenesis and mainly mitochondrial fusion and reduced mitophagy, contribute to the metabolic disorder and inflammation that occurs during OA. Reduced MFN2 and increased PARKIN expression represent potential therapeutic targets for the treatment of joint cartilage degradation during the OA process.
Identifiants
pubmed: 32417558
pii: S1063-4584(20)30996-1
doi: 10.1016/j.joca.2020.03.018
pii:
doi:
Types de publication
Editorial
Research Support, Non-U.S. Gov't
Comment
Langues
eng
Sous-ensembles de citation
IM
Pagination
1003-1006Commentaires et corrections
Type : CommentOn
Informations de copyright
Copyright © 2020 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.