Opposite Modulatory Effects of Crataegus aronia Aqueous Extract on Platelet Aggregation in Rats.
Crataegus aronia
Intracellular cyclic adenosine monophosphate
P2Y12
aggregation
nuclear factor αB
platelets
reactive oxygen species
Journal
Chinese journal of integrative medicine
ISSN: 1993-0402
Titre abrégé: Chin J Integr Med
Pays: China
ID NLM: 101181180
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
accepted:
13
05
2019
pubmed:
18
5
2020
medline:
26
11
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
To reveal the mechanisms behind the dual effects of Crataegus aronia (C. aronia) aqueous extract on platelet aggregation by focusing on function, regulation, expression, and signaling of platelets P Adult male Wistar rats (120 ± 10 g) were classified as control received the vehicle, C. aronia (200 mg/kg), and C. aronia (2,000 mg/kg)-treated rats. After treatments for consecutive 7 days, hematological and molecular experiments were conducted to detect alterations in platelet aggregation, thromboxane B2 (THXB2) and intracellular reactive oxygen species (ROS) content; protein levels of P At a concentration of 200 mg/kg, C. aronia inhibited platelet aggregation through multiple interconnected mechanisms including downregulation P Oral administration of C. aronia at low dose inhibits platelet aggregation by reducing THXB2 release, expression of P-selectin and activating cAMP and Akt signaling through two major mechanisms including downregulation of P
Identifiants
pubmed: 32418179
doi: 10.1007/s11655-020-3187-3
pii: 10.1007/s11655-020-3187-3
doi:
Substances chimiques
Plant Extracts
0
Platelet Aggregation Inhibitors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
696-704Informations de copyright
© 2020. The Chinese Journal of Integrated Traditional and Western Medicine Press and Springer-Verlag GmbH Germany, part of Springer Nature.
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