Relationship of oxidative stress to visceral adiposity in youth and role played by vitamin D.
Adiposity
/ physiology
Adolescent
Antioxidants
/ metabolism
Child
Female
Humans
Intra-Abdominal Fat
/ diagnostic imaging
Luxembourg
/ epidemiology
Magnetic Resonance Imaging
Male
Obesity, Abdominal
/ complications
Overweight
/ complications
Oxidative Stress
/ physiology
Pediatric Obesity
/ complications
Risk Factors
Vitamin D
/ blood
Vitamin D Deficiency
/ complications
antioxidant
children
obesity
visceral fat
vitamin
Journal
Pediatric diabetes
ISSN: 1399-5448
Titre abrégé: Pediatr Diabetes
Pays: Denmark
ID NLM: 100939345
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
16
12
2019
revised:
22
04
2020
accepted:
08
05
2020
pubmed:
18
5
2020
medline:
15
7
2021
entrez:
18
5
2020
Statut:
ppublish
Résumé
Visceral adipose tissue (VAT) accumulation is a major cardiometabolic risk factor, associated with increased inflammation. Oxidative stress (OS) is also associated with inflammation and cardiometabolic issues, yet mainly through general obesity. Both OS and obesity were linked to vitamin D deficiency. To investigate whether OS increase is associated with VAT accumulation in youth, and whether in the presence of VAT accumulation, a higher vitamin D status is associated with lower OS. One hundred and fifty-eight youth with overweight/obesity, 7 to 17 years old, were recruited (Pediatric Clinic, Luxembourg). We assessed visceral and subcutaneous abdominal adipose tissues by magnetic resonance imaging, OS by DNA/RNA oxidative damage with ELISA and vitamin D by high-performance liquid chromatography. VAT was the body fat compartment the most strongly associated with OS (R Dietary strategies improving vitamin D status should be investigated to tackle VAT and OS increase.
Sections du résumé
BACKGROUND
Visceral adipose tissue (VAT) accumulation is a major cardiometabolic risk factor, associated with increased inflammation. Oxidative stress (OS) is also associated with inflammation and cardiometabolic issues, yet mainly through general obesity. Both OS and obesity were linked to vitamin D deficiency.
OBJECTIVES
To investigate whether OS increase is associated with VAT accumulation in youth, and whether in the presence of VAT accumulation, a higher vitamin D status is associated with lower OS.
METHODS
One hundred and fifty-eight youth with overweight/obesity, 7 to 17 years old, were recruited (Pediatric Clinic, Luxembourg). We assessed visceral and subcutaneous abdominal adipose tissues by magnetic resonance imaging, OS by DNA/RNA oxidative damage with ELISA and vitamin D by high-performance liquid chromatography.
RESULTS
VAT was the body fat compartment the most strongly associated with OS (R
CONCLUSION
Dietary strategies improving vitamin D status should be investigated to tackle VAT and OS increase.
Substances chimiques
Antioxidants
0
Vitamin D
1406-16-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
758-765Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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